图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.2017024564
pages 905-913

A Primary Study of the Antioxidant, Hypoglycemic, Hypolipidemic, and Antitumor Activities of Ethanol Extract of Brown Slimecap Mushroom, Chroogomphus rutilus (Agaricomycetes)

Jinxiu Zhang
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Xiaojing Zhao
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Li Qiang Zhao
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Junxia Zhao
The Basic Medical College, Hebei Medical University, Shijiazhuang, People's Republic of China
Zhiguang Qi
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Li-An Wang
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China

ABSTRACT

In vivo and in vitro treatments were carried out to investigate the effects of a 95% ethanol extract of Chroogomphus rutilus (CRE) on antioxidant, hypoglycemic, hypolipidemic, and antitumor properties. CRE showed potent radical scavenging activity against DPPH in vitro. It could increase antioxidant enzymatic activities (superoxide dismutase and glutathione peroxidase) and could reduce malondialdehyde content in vivo in mice in which aging was induced by D-galactose. CRE had hypoglycemic activity and could significantly inhibit α-glucosidase activity in vitro and decrease blood glucose concentration in vivo. CRE could decrease the serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels and increase the high-density lipoprotein cholesterol level in diabetic mice. The MTT assay showed that CRE also had a certain inhibitory effect on the tumor cells. These results suggest that CRE may be beneficial for human health and could be useful for applications in medicine, the food industry, and agriculture.


Articles with similar content:

Evaluation of the Antioxidative and Hypo-cholesterolemic Effects of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Ameliorating Cardiovascular Disease
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 10
Mohammad Azizur Rahman, Norhaniza Aminudin, Noorlidah Abdullah
Colono-protective Potentiality of Methanolic Bark Extract of Acacia catechu: A Medicinal Plant against 1,2-Dimethylhydrazine–Induced Toxicity in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 4
Abul Vafa, Rahat Ali, Sarwat Sultana, Aisha Siddiqi, Alpashree, Preeti Barnwal, Syed Kazim Hasan, Shekh Mohammad Afzal, Johirul Islam
Mitigating Acetaminophen-Induced Hepatotoxicity by Using a Water-Alcohol Extract of Phellinus caryophylli (Agaricomycetes) in a Murine Model
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 4
Cherupally Krishnan Krishnan Nair, Prasad Y. Lamrood, Yogesh Bharat Dalvi, Ruby Varghese
Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Akbar Masood, Ovais Zargar, Mohammad Afzal Zargar, Showkat Ahmad Ganie, Shajrul Amin, Parvaiz Ahmad Dar, Shayaq Ul Abeer, Rabia Hamid, Tanveer Ali Dar, Bilal Zargar
Antihyperglycemic and Antilipidperoxidative Effects of Polysaccharides Extracted from Medicinal Mushroom Chaga, Inonotus obliquus (Pers.: Fr.) Pilát (Aphyllophoromycetideae) on Alloxan-Diabetes Mice
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 3
Yitong Zheng, Hongyu Xu, Xin Xu, Zhenming Lu, Chengjian Yang, Zheng-Hong Xu, Chong Pang