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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v17.i9.80
pages 879-889

A Water-Ethanol Extract from the Willow Bracket Mushroom, Phellinus igniarius (Higher Basidiomycetes), Reduces Transient Cerebral Ischemia-Induced Neuronal Death

Jin Hee Kim
Institute of Medical Science, Hallym University, Chuncheon, Republic of Korea
Bo Young Choi
Institute of Medical Science, Hallym University, Chuncheon, Republic of Korea
Hyun Jung Kim
Institute of Medical Science, Hallym University, Chuncheon, Republic of Korea
In Yeol Kim
Department of Physiology, College of Medicine, Hallym University, Chuncheon, Republic of Korea
Bo Eun Lee
Institute of Medical Science, Hallym University, Chuncheon, Republic of Korea
Min Sohn
Department of Nursing, Inha University, Incheon, Republic of Korea
Hyoung Jin Park
MushMed Co., Ltd, Chuncheon, Gangwon-do, Republic of Korea
Sang Won Suh
Institute of Medical Science, Hallym University, Chuncheon, Republic of Korea

ABSTRACT

This study investigated the potential neuroprotective effect of a mushroom extract from Phellinus igniarius (Piwep) after transient cerebral ischemia. Ph. Igniarius, which has a history of traditional medicinal use, contains immunomodulatory compounds that have been described to have effects on the human immune system. Using a model of transient cerebral ischemia induced by both common carotid artery occlusion and hypovolemia, a water−ethanol extract precipitate of Ph. Igniarius (Piwep) was delivered intraperitoneally immediately after the insult and was injected subsequently every other day for the experimental course. Neuronal death was examined by Fluoro-Jade B staining 1 week after the insult. Piwep injection lead to decreased hippocampal neuronal death, suppression of oxidative injury, activation of microglia, and disruption of the blood−brain barrier. We conclude that Piwep potently inhibits hippocampal neuronal death following ischemia and may have a high therapeutic potential for ameliorating stroke-induced neuron death in the clinical setting.


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