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国际药用蘑菇期刊

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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Protective Efficacy of the Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes), from India in Neuronal Hippocampal Cells against Hypoxia

卷 17, 册 9, 2015, pp. 829-840
DOI: 10.1615/IntJMedMushrooms.v17.i9.30
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摘要

This study demonstrated the protective efficiency of extracts of the Indian variety of Ophiocordyceps sinensis (=Cordyceps sinensis) (CSEs) in HT22 (murine hippocampal) cells under hypoxic conditions. Various parameters such as cell viability, reactive oxygen species, levels of endogenous antioxidants, inflammatory cytokines, transcription factors, and oxidation of macromolecules were analyzed. In addition, the radical scavenging abilities of hydroxyl radicals, nitric oxide, and superoxide radicals were also studied. Antioxidant compounds, ascorbic acid, hesperidin, and rutin were quantified by high-performance thin-layer chromatography. The information acquired from high-performance thin-layer chromatography profiling was subjected to principal component analysis for data clustering. Findings of this research revealed that ascorbic acid and rutin were highest in aqueous CSE, whereas the maximum amount of hesperidin was found in 25% alcoholic CSE. In vitro studies showed that all the CSEs protected HT22 cells well by upregulating the level of endogenous antioxidants and preventing the oxidation of lipids and proteins. These extracts also reduced the amount of hypoxia-induced inflammatory cytokines and transcription factors on par with the normoxic control with more or less equal protection in the cells under hypoxia, and indicated significant radical scavenging potential.

对本文的引用
  1. Rakhee , Mishra Jigni, Sharma Raj K., Misra Kshipra, Characterization Techniques for Herbal Products, in Management of High Altitude Pathophysiology, 2018. Crossref

  2. Pal Mamta, Misra Kshipra, Cordyceps sp.: The Precious Mushroom for High-Altitude Maladies, in Management of High Altitude Pathophysiology, 2018. Crossref

  3. Mishra Jigni, Bhardwaj Anuja, Pal Mamta, Rajput Rakhee, Misra Kshipra, High performance thin layer chromatography hyphenated with electrospray mass spectrometry for evaluation of nucleobases in two traditional Chinese medicinal mushrooms: A metabolomic approach, Journal of Liquid Chromatography & Related Technologies, 41, 15-16, 2018. Crossref

  4. Rakhee , Mishra Jigni, Yadav Renu Bala, Meena D. K., Arora Rajesh, Sharma R. K., Misra Kshipra, Novel formulation development from Ophiocordyceps sinensis (Berk.) for management of high-altitude maladies, 3 Biotech, 11, 1, 2021. Crossref

  5. Mishra Jigni, Khan Washim, Ahmad Sayeed, Misra Kshipra, Supercritical Carbon Dioxide Extracts of Cordyceps sinensis: Chromatography-based Metabolite Profiling and Protective Efficacy Against Hypobaric Hypoxia, Frontiers in Pharmacology, 12, 2021. Crossref

  6. Sørnes Elise Øien, Risal Ajay, Manandhar Kedar, Thomas Hallie, Steiner Timothy J, Linde Mattias, Use of medicinal plants for headache, and their potential implication in medication-overuse headache: Evidence from a population-based study in Nepal, Cephalalgia, 41, 5, 2021. Crossref

  7. Long Hailin, Qiu Xuehong, Cao Li, Han Richou, Discovery of the signal pathways and major bioactive compounds responsible for the anti-hypoxia effect of Chinese cordyceps, Journal of Ethnopharmacology, 277, 2021. Crossref

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