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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Mechanism Underlying the Antitumor Activity of Proteins from the Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) In Vitro

卷 12, 册 2, 2010, pp. 133-139
DOI: 10.1615/IntJMedMushr.v12.i2.30
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摘要

The extracts of Ganoderma lucidum (Ling Zhi or Reishi) medicinal mushroom show antitumor activity in vivo. The functional activities of proteins from G. lucidum or selenium-enriched G. lucidum (Se-G. lucidum) have been reported in many studies. However, the mechanism underlying the antitumor activity of proteins from G. lucidum has not been clarified. It is interesting to know how selenium influences the antitumor activity of the proteins in Se-G. lucidum. In the present study, the inhibitory effects of protein extracts from G. lucidum and Se-G. lucidum on several tumor cells were investigated, and the activities of the mixtures of these proteins and inorganic selenium (Na2SeO3) were compared under the same conditions. Results showed that Na2SeO3 and Se-GL-P exhibit relatively high activity among six samples to inhibit the multiplication of tumor cells. The incorporation of Se into the proteins, in the form of selenocysteine and selenomethionine, apparently enhances their activity. Na2SeO3 does not exhibit effective antitumor activity unless the concentration is high enough. In conclusion, the immune-regulation activity and selenium-containing property of proteins from G. lucidum or Se-G. lucidum presumably contribute to their antitumor activity.

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