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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Extracts of Medicinal Mushrooms Agaricus bisporus and Phellinus linteus Induce Proapoptotic Effects in the Human Leukemia Cell Line K562

卷 12, 册 2, 2010, pp. 167-175
DOI: 10.1615/IntJMedMushr.v12.i2.70
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摘要

We have studied the effects of Agaricus bisporus and Phellinus linteus ethanol extracts on transcriptional regulation of genes involved in cytokine release and apoptosis in the human leukemia cell line K562. In particular, we applied quantitative real-time PCR (Q-PCR) assays to monitor alterations of gene expression for the following genes: Bcl-2, Casp-9, NF-κB, TNF-α, IFN-γ, and IL-10. We found stronger proapoptotic activity for the Ph. linteus alcohol extract on K562 cells than for the A. bisporus extract: 4.4- and 2.2-fold increase of Bcl-2 and Casp-9 transcripts. Mushroom alcohol extracts are suggested to exert their effects on tumor cells via the induction of apoptosis. K562 leukemia cells were shown to be most responsive to the transcriptional induction of tumor necrosis factor TNF-α when stimulated with IFN-γ and then treated with Ph. linteus alcohol extract: up to a 4.5-fold increase. Treatment of K562 cells with A. bisporus extract promoted transcription of the cytokine gene IL-10.

对本文的引用
  1. Parniakov O., Lebovka N. I., Van Hecke E., Vorobiev E., Pulsed Electric Field Assisted Pressure Extraction and Solvent Extraction from Mushroom (Agaricus Bisporus), Food and Bioprocess Technology, 7, 1, 2014. Crossref

  2. Roselló-Soto Elena, Parniakov Oleksii, Deng Qian, Patras Ankit, Koubaa Mohamed, Grimi Nabil, Boussetta Nadia, Tiwari Brijesh K., Vorobiev Eugène, Lebovka Nikolai, Barba Francisco J., Application of Non-conventional Extraction Methods: Toward a Sustainable and Green Production of Valuable Compounds from Mushrooms, Food Engineering Reviews, 8, 2, 2016. Crossref

  3. Smiderle Fhernanda R., Sassaki Guilherme L., Arkel Jeroen van, Iacomini Marcello, Wichers Harry J., Griensven Leo J.L.D. Van, High Molecular Weight Glucan of the Culinary Medicinal Mushroom Agaricus bisporus is an α-Glucan that Forms Complexes with Low Molecular Weight Galactan, Molecules, 15, 8, 2010. Crossref

  4. Badshah Syed Lal, Riaz Anila, Muhammad Akhtar, Tel Çayan Gülsen, Çayan Fatih, Emin Duru Mehmet, Ahmad Nasir, Emwas Abdul-Hamid, Jaremko Mariusz, Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta, Molecules, 26, 5, 2021. Crossref

  5. Kumar Krishan, Mehra Rahul, Guiné Raquel P. F., Lima Maria João, Kumar Naveen, Kaushik Ravinder, Ahmed Naseer, Yadav Ajar Nath, Kumar Harish, Edible Mushrooms: A Comprehensive Review on Bioactive Compounds with Health Benefits and Processing Aspects, Foods, 10, 12, 2021. Crossref

  6. Chen Hua, Tian Ting, Miao Hua, Zhao Ying-Yong, Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus: A review, Fitoterapia, 113, 2016. Crossref

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