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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Macrophages Stimulated by Polysaccharide Purified from Agaricus brasiliensis S.Wasser et al. (Agaricomycetideae) Enhance mRNA Expression of Th1 Cytokine Including IL-12 and 18

卷 5, 册 4, 2003, 8 pages
DOI: 10.1615/InterJMedicMush.v5.i4.50
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Masashi Mizuno
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Japan
Sachiko Kawakami
Graduate School of Science and Technology, Kobe University, Kobe, Japan
Nobuhide Fujitake
Faculty of Agriculture, Kobe University, Kobe, Japan

摘要

Royal Sun Agaricus—Agaricus brasiliensis—has traditionally and medically been used as a health food for the prevention of cancer. We chromatographically purified an immunomodulating compound from a water-soluble fraction of A. brasiliensis. The molecular weight of this compound was determined as approximately 6200 by gel permeation chromatography. This compound enhanced the production of tumor necrosis factor (TNF)-a and nitric oxide (NO) from a murine macrophage-like cell line, RAW264.7. The result of time-course experiments on TNF-a and NO production from RAW264.7 indicated that TNF-a production was produced at least 6 hours earlier than NO production. The expression of interleukin (IL)-12 (a key role in Th1 differentiation) and IL-18 (a proinflammatory cytokine in enhancing Th1 immune response) mRNA in RAW264.7 was investigated by RT-PCR. Both mRNAs were induced 24 hours after stimulation. In conclusion, autocrine TNF-a production caused NO production from macrophage stimulated by the immunomodulating compound from A. brasiliensis. In addition, this compound might activate Th1 immune response because it increased the level of IL-12 and 18 mRNA expressions in macrophages.

对本文的引用

  1. Shu Chin-Hang, Xu Chun-Jun, Lin En-Shu, Production, purification and partial characterization of a novel endo-β-1,3-glucanase from Agaricus brasiliensis, Process Biochemistry, 41, 5, 2006. Crossref

  2. Park Hyun-Ji, Heo Yong, Kim Jong-Bong, Immunomodulating Effect of Edible Mushrooms in Mice, Journal of Life Science, 21, 4, 2011. Crossref

  3. Tanoue Takeshi, Nishitani Yosuke, Kanazawa Kazuki, Hashimoto Takashi, Mizuno Masashi, In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells, Biochemical and Biophysical Research Communications, 374, 3, 2008. Crossref

  4. Navegantes Kely C., Albuquerque Rosyana F. V., Dalla-Santa Herta S., Soccol Carlos R., Monteiro Marta C., Agaricus brasiliensismycelium and its polysaccharide modulate the parameters of innate and adaptive immunity, Food and Agricultural Immunology, 24, 4, 2013. Crossref

  5. Moradali Mohammad-Fata, Mostafavi Hossein, Ghods Shirin, Hedjaroude Ghorban-Ali, Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi), International Immunopharmacology, 7, 6, 2007. Crossref

  6. Mizuno Masashi, In Vitro and In Vivo Immunomodulatory and Anti-allergic Effects of Agaricus blazei Murill, in Dietary Components and Immune Function, 2010. Crossref

  7. Nishitani Yosuke, Mizuno Masashi, Anti-inflammatory Activities of <i>Lactococcus lactis</i> subsp. <i>cremoris</i> FC in <i>In Vitro</i> and <i>In Vivo</i> Gut Inflammation Models, Bioscience and Microflora, 29, 4, 2010. Crossref

  8. Rahman Md. Mahbubur, Mosaddik Ashik, Alam AHM Khurshid, Traditional foods with their constituent's antiviral and immune system modulating properties, Heliyon, 7, 1, 2021. Crossref

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