图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushr.v2.i2.30
7 pages

Effect of Ganoderma tsugae Murr. (Aphyllophoromycetideae) and Vitamin E Supplementation on Enzyme Activities in the Liver and Plasma of Normal and Chemically Induced Hepatocarcinogenic Rats

Nor Aripin Shamaan
Department of Biochemistry and Microbiology, Universiti Putra Malaysia, 43400 UPM Serdang, Malaysia
Z. Jarien
Department of Biochemistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
B. A. K. Khalid
Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
A. G. M. Top
Division of Chemistry and Technology. Palm Oil Research Institute of Malaysia, Jalan Persiaran llmu, Bandar Baru Bangi. 43600 Bangi, Malaysia
W. Z. Wan Ngah
Department of Biochemistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

ABSTRACT

Ganoderma tsugae Murr. and vitamin E (α-tocopherol and γ-tocotrienol) were supplemented, alone and combined, to normal rats and rats chemically induced with cancer using a single injection of diethylnitrosamine followed by 0.2% (w/v) 2-acetylaminofluorene and partial hepatectomy. The rats were treated for 16 weeks before they were killed. The activities of alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γGTP), glutathione S-transferase (GST), and uridyldiphosphate glucuronyltransferase (UDPGT) in plasma and subcellular fractions were determined. Blood glutathione levels were also determined. The activities of γGTP and placental GST were determined histochemically in the liver. The ratio of liver to body weight was significantly increased in the cancer-induced rats compared with normal controls. The ratios were unchanged after G. tsugae and vitamin E supplementation. Blood glutathione levels were significantly higher in the cancer-induced rats than normal controls. Supplementation of G. tsugae and vitamin E lowered blood glutathione levels to normal values. The enzyme activities in the subcellular fractions were higher in the cancer-induced rats than in normal controls. The activities were substantially attenuated upon G. tsugae and vitamin E supplementation. Attenuation of the enzyme-positive foci was also evident upon G. tsugae and vitamin E supplementation in the cancer-induced rats. G. tsugae supplementation that started 3 weeks after cancer induction resulted in a similar effect to G. tsugae supplementation started simultaneously with cancer induction.


Articles with similar content:

Curative Effect of Amorphophallus campanulatus (Roxb.) Blume. Tuber On N-Nitrosodiethylamine- Induced Hepatocellular Carcinoma in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 3
Santhibhavan Prabhakaran Prabha, Anand Nitha, Puthuparampil Nazarudeen Ansil, Mukalel Sankunni Latha
Effect of Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. Mycelium on Benzo[a]prene-Induced Early Alterations of the Respiratory Epithelium in the Hypercholesterolaemic Rats
International Journal of Medicinal Mushrooms, Vol.9, 2007, issue 2
Suhaila Mohamed, Chow Chin Tong, Nor Aini B. Umar, Mohamed Mustapha Noordin, Yew Keong Choong
Asthma-Alleviating Potential of 6-Gingerol: Effect on Cytokines, Related mRNA and c-Myc, and NFAT1 Expression in Ovalbumin-Sensitized Asthma in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.38, 2019, issue 1
S. Vadivukkarasi, P. Brahmanaidu, Ponmurugan Ponnusamy, Santhanaraj Balakrishnan, V. V. Sathibabu Uddandrao, Zhongxi Liu , Saravanan Ganapathy, Zaoni Li
The Effects of a Powder of the Fruiting Body of Commercial Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (W.Curt.:Fr.) P.Karts.,] on Hypercholesterolemic Rat Skin, Applied With a Topical Application of Benzo(a)pyrene
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 4
Nor Aini B. Umar, Sulaila Mohamad, Tong Chow Chin, Choong Yew Keong, Noordin M. Mustapha
Protective Effects of Picorrhiza Kurroa Extract against 2-Acetylaminofluorene-Induced Hepatotoxicity in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 3
Sarwat Sultana, Sahar Rahman