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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Effect of Ganoderma tsugae Murr. (Aphyllophoromycetideae) and Vitamin E Supplementation on Enzyme Activities in the Liver and Plasma of Normal and Chemically Induced Hepatocarcinogenic Rats

卷 2, 册 2, 2000, 7 pages
DOI: 10.1615/IntJMedMushr.v2.i2.30
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摘要

Ganoderma tsugae Murr. and vitamin E (α-tocopherol and γ-tocotrienol) were supplemented, alone and combined, to normal rats and rats chemically induced with cancer using a single injection of diethylnitrosamine followed by 0.2% (w/v) 2-acetylaminofluorene and partial hepatectomy. The rats were treated for 16 weeks before they were killed. The activities of alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γGTP), glutathione S-transferase (GST), and uridyldiphosphate glucuronyltransferase (UDPGT) in plasma and subcellular fractions were determined. Blood glutathione levels were also determined. The activities of γGTP and placental GST were determined histochemically in the liver. The ratio of liver to body weight was significantly increased in the cancer-induced rats compared with normal controls. The ratios were unchanged after G. tsugae and vitamin E supplementation. Blood glutathione levels were significantly higher in the cancer-induced rats than normal controls. Supplementation of G. tsugae and vitamin E lowered blood glutathione levels to normal values. The enzyme activities in the subcellular fractions were higher in the cancer-induced rats than in normal controls. The activities were substantially attenuated upon G. tsugae and vitamin E supplementation. Attenuation of the enzyme-positive foci was also evident upon G. tsugae and vitamin E supplementation in the cancer-induced rats. G. tsugae supplementation that started 3 weeks after cancer induction resulted in a similar effect to G. tsugae supplementation started simultaneously with cancer induction.

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