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国际药用蘑菇期刊
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ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v16.i4.30
pages 327-337

Anticancer and Antimicrobial Activities and Chemical Composition of the Birch Mazegill Mushroom Lenzites betulina (Higher Basidiomycetes)

Kun Liu
College of Life and Environmental Sciences, Minzu University of China, Beijing, People's Republic of China; College of Biology Science and Engineering, Hebei University of Economics and Business, Shijiazhuang, Hebei, People's Republic of China
Jun-Li Wang
College of Life and Environmental Sciences, Minzu University of China, Beijing, People's Republic of China
Le Zhao
College of Life and Environmental Sciences, Minzu University of China, Beijing, People's Republic of China
Qian Wang
College of Life and Environmental Sciences, Minzu University of China, Beijing, People's Republic of China

ABSTRACT

The anticancer properties, antibiotic activity, and chemical composition of Lenzites betulina ethanol extract (EE) were evaluated. Eight compounds including 5 sterols were isolated from L. betulina, and 7 compounds were isolated from L. betulina for the first time. The EE displayed strong anticancer activity against tumor cell line MDA-MB-231, with a half maximal inhibitory concentration of 51.46 μg/mL, and there was 83.15% inhibition at a concentration of 200 μg/mL (MTT assay). The antimicrobial activity of the EE was evaluated against 6 microorganisms−Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Fusarium graminearum, Gibberella zeae, and Cercosporella albo-maculans−and the EE showed moderate antibiotic activity. These results suggest that L. betulina could be a good anticancer and antibiotic agent.


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