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国际药用蘑菇期刊
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ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v18.i10.60
pages 905-913

Antimicrobial Coumarins from the Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), from Kenya

Lilechi D. Baraza
Department of Pure and Applied Chemistry, Masinde Muliro University of Science and Technology, Kakamega, Kenya
Wekesa Neser
Department of Pure and Applied Chemistry, Masinde Muliro University of Science and Technology, Kakamega, Kenya
Korir Cheruiyot Jackson
Department of Biological Sciences, Masinde Muliro University of Science and Technology, Kakamega, Kenya
Juma B. Fredrick
Department of Pure and Applied Chemistry, Masinde Muliro University of Science and Technology, Kakamega, Kenya
Ochieno Dennis
Department of Biological Sciences, Masinde Muliro University of Science and Technology, Kakamega, Kenya
Kamau R. Wairimu
Department of Pure and Applied Chemistry, Masinde Muliro University of Science and Technology, Kakamega, Kenya
Aggrey Osogo Keya
Department of Biological Sciences, Masinde Muliro University of Science and Technology, Kakamega, Kenya
Matthias Heydenreich
Universität Potsdam, Institut für Chemie, Potsdam, Germany

ABSTRACT

Pleurotus ostreatus has been widely used as food because of its nutritional and medicinal properties. These have been attributed to the presence of macronutrients, minerals, vitamins, and amino acids, among other secondary metabolites. There are, however, few reports on the antimicrobial activities of different classes of purified compounds from P. ostreatus. This led to the current study, the objective of which was to chemically characterize the antibiotic activities of P. ostreatus against selected human pathogenic bacteria and endophytic fungi. Chemical structures were determined using spectroscopic methods and by comparison with values of related structures reported in the literature. Pure compounds from P. ostreatus were tested in vitro against pathogenic bacteria (Staphylococcus aureus and Escherichia coli) and endophytic fungi (Pencillium digitatum and Fusarium proliferatum). A new compound, (E)-5,7-dimethoxy-6-(3-methylbuta-1,3-dienyl)-2H-chromen-2-one (5-methoxy-(E)-suberodiene) (compound 2), along with ergosterol (compound 1) and 5,7-dimethoxy-6-(3-methylbut-2-enyl)-2H-chromen-2-one (toddaculin; compound 3), were isolated from the fruiting bodies of P. ostreatus. The growth of S. aureus, F. proliferatum, and P. digitatum colonies was inhibited in media containing compound 2, with minimum inhibitory concentrations closely comparable to those of conventional antibiotics.


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