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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.2017024492
pages 767-775

In Vitro and In Vivo Antitumoral Activity of Exobiopolymers from the Royal Sun Culinary-Medicinal Mushroom Agaricus brasiliensis (Agaricomycetes)

Vanessa Sovrani
Department of Biochemistry and Molecular Biology, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
Juliana da Rosa
Department of Biology, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil
Mariana de Paula Drewinski
Department of Biology, Universidade Federal de Santa Catarina, Florianopólis, Santa Catarina, Brazil
Franciely Grose Colodi
Department of Biochemistry and Molecular Biology, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
Tânia Toyomi Tominaga
Department of Physics, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil
Herta Stutz Dalla Santa
Bioprocess Engineering and Biotechnology Division, Federal University of Paraná, Curitiba, Paraná, Brazil
Rosilene Rebeca
Department of Biology, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil

ABSTRACT

We studied antitumor activity in vitro and in vivo and partial chemical characterization of exobiopolymers (EBPs) of Agaricus brasiliensis produced by submerged cultivation. The EBPs comprised 61.2% total sugar and 22.3% total protein, and the chromatographic profile mainly identified mannose (65.5%), galactose (17.5%), and glucose (13.1%). In vitro analysis revealed a dose with antitumor effectiveness, time-dependent treatment, and 46% inhibition of solid Walker 256 tumors in rats. Metabolic changes were significant in the spleens of the animals; this is possibly related to higher immune activity triggered by the presence of EBPs in the treated group. The increase of nitric oxide production by peritoneal macrophages from animals may be related to the tumor reduction observed, because nitric oxide acts as an important effector pathway in the defense of the organism.


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