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ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Dichlormethane Extract of the Jelly Ear Mushroom Auricularia auricula-judae (Higher Basidiomycetes) Inhibits Tumor Cell Growth In Vitro

卷 16, 册 1, 2014, pp. 37-47
DOI: 10.1615/IntJMedMushr.v16.i1.40
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摘要

In this study, a dichloromethane fraction (DCMF) from 70% Auricularia auricula-judae ethanol extract showed the highest level of antitumor activity compared to other solvent fractions (ethyl acetate, butanol, and water). The DCMF was found to have more potent antitumor activity against broncheoalveolar cancer (half maximal inhibitory concentration = 57.2 µg/mL) and gastric cancer cells (half maximal inhibitory concentration = 73.2 µg/mL) compared to the other solvent fractions, although all fractions inhibited the proliferation of the tumor cells in a dose-dependent manner. We further analyzed the DCMF composition by gas chromatography−coupled mass spectroscopy. Based on the results of this analysis, an antitumor active component (diazane) was identified in the DCMF. However, we found that diazane alone had a lower level of antitumor activity than the DCMF. These findings indicate that other unknown components of the DCMF also are responsible for the cytotoxic effects of DCMF against tumor cells. Semiquantitative reverse transcription polymerase chain reaction analysis demonstrated that DCMF induced cytotoxicity or tumor cell apoptosis as a result of the downregulation of Bcl-2 expression and p53 overexpression. Taken together, our study results demonstrated that the DCMF may be used as a functional additive for enhancing antioxidant activities and suppressing tumor growth in the body.

对本文的引用
  1. Hossain Md. Akil, Lee Seung-Jin, Park Ji-Yong, Reza Md. Ahsanur, Kim Tae-Hwan, Lee Ki-Ja, Suh Joo-Won, Park Seung-Chun, Modulation of quorum sensing-controlled virulence factors by Nymphaea tetragona (water lily) extract, Journal of Ethnopharmacology, 174, 2015. Crossref

  2. Valverde María Elena, Hernández-Pérez Talía, Paredes-López Octavio, Edible Mushrooms: Improving Human Health and Promoting Quality Life, International Journal of Microbiology, 2015, 2015. Crossref

  3. Sun Shujing, Zhang Xiaojuan, Sun Shiwei, Zhang Liaoyuan, Shan Shukai, Zhu Hu, Production of natural melanin by Auricularia auricula and study on its molecular structure, Food Chemistry, 190, 2016. Crossref

  4. ZHUAN-YUN LI, XUE-PING YAO, BIN LIU, REHEMAN HA NIZAIER, YANG GAO, ZHAN SUN, QI MA, Auricularia auricular-judae polysaccharide attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress and inflammation, Biomedical Reports, 3, 4, 2015. Crossref

  5. Hossain Md. Akil, Lee Seung-Jin, Park Na-Hye, Mechesso Abraham Fikru, Birhanu Biruk Tesfaye, Kang JeongWoo, Reza Md. Ahsanur, Suh Joo-Won, Park Seung-Chun, Impact of phenolic compounds in the acyl homoserine lactone-mediated quorum sensing regulatory pathways, Scientific Reports, 7, 1, 2017. Crossref

  6. Varghese Ruby, Dalvi Yogesh Bharat, Lamrood Prasad Y., Shinde Bharat P., Nair C. K. K., Historical and current perspectives on therapeutic potential of higher basidiomycetes: an overview, 3 Biotech, 9, 10, 2019. Crossref

  7. Zhao Yuhui, Wang Liang, Zhang Dongshan, Li Rong, Cheng Tianyou, Zhang Yibi, Liu Xueju, Wong Gary, Tang Yuguo, Wang Hui, Gao Shan, Comparative transcriptome analysis reveals relationship of three major domesticated varieties of Auricularia auricula-judae, Scientific Reports, 9, 1, 2019. Crossref

  8. Sun Jian, Wang Shixin, Wang Xutong, Sun Tingting, Zou Li, Cloning and expression analyses of a cellobiohydrolase gene from Auricularia heimuer, Biotechnology & Biotechnological Equipment, 33, 1, 2019. Crossref

  9. Gründemann Carsten, Reinhardt Jakob K., Lindequist Ulrike, European medicinal mushrooms: Do they have potential for modern medicine? – An update, Phytomedicine, 66, 2020. Crossref

  10. Jin Yanxia, Cai Liqin, Yang Qian, Luo Ziyi, Liang Li, Liang Yuxing, Wu Balu, Ding Lu, Zhang Dongdong, Xu Xiaojuan, Zhang Lina, Zhou Fuling, Anti-leukemia activities of selenium nanoparticles embedded in nanotube consisted of triple-helix β-d-glucan, Carbohydrate Polymers, 240, 2020. Crossref

  11. Khatua Somanjana, Sett Susmita, Acharya Krishnendu, Auricularia spp.: from Farm to Pharmacy, in Biology, Cultivation and Applications of Mushrooms, 2022. Crossref

  12. Nowakowski Patryk, Markiewicz-Żukowska Renata, Bielecka Joanna, Mielcarek Konrad, Grabia Monika, Socha Katarzyna, Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents, Biomedicine & Pharmacotherapy, 143, 2021. Crossref

  13. Islam Tahidul, Ganesan Kumar, Xu Baojun, Insights into health-promoting effects of Jew's ear (Auricularia auricula-judae), Trends in Food Science & Technology, 114, 2021. Crossref

  14. Pak SolJu, Chen Fang, Ma Lingjun, Hu Xiaosong, Ji Junfu, Functional perspective of black fungi (Auricularia auricula): Major bioactive components, health benefits and potential mechanisms, Trends in Food Science & Technology, 114, 2021. Crossref

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