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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushr.v14.i1.30
pages 27-36

Hypolipidemic and Antiatherogenesis Effect of Culinary-Medicinal Pink Oyster Mushroom, Pleurotus salmoneostramineus L. Vass. (Higher Basidiomycetes), in Hypercholesterolemic Rats

Ki Nam Yoon
Division of Life Sciences, University of Incheon, Incheon 406-840, Republic of Korea
Nuhu Alam
Division of Life Sciences, University of Incheon, Incheon 406-840, Republic of Korea;Department of Botany, Jahangirnagar University, Savar, Dahka 1342, Bangladesh
Mi Ja Shim
College of Pharmacy, Seoul National University, Seoul 151-742; and Department of Life Science, University of Seoul, Seoul 130-743, Korea
Tae Soo Lee
Division of Life Sciences, Incheon National University, Yeonsu-gu, Incheon 406-840, Republic of Korea

ABSTRACT

The present study was conducted to investigate dietary supplementation of Pleurotus salmoneostramineus fruiting bodies on biochemical and histological effects in hyper- and normocholesterolemic rats. Six-week-old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Feeding of diet containing a 5% powder of the fruiting bodies of P. salmoneostramineus in hypercholesterolemic rats reduced plasma total cholesterol, triglyceride, low-density lipoprotein, total lipid, phospholipids, and LDL/HDL ratio by 22.55, 51.38, 69.23, 29.67, 16.61, and 65.31%, respectively. The mushroom also significantly reduced body weight in hypercholesterolemic rats. Moreover, it had no adverse effects on plasma albumin, total bilirubin, direct bilirubin, creatinine, blood urea nitrogen, uric acid, glucose, total protein, calcium, sodium, potassium, chloride, inorganic phosphate, magnesium, and enzyme profiles. Feeding mushroom increased total lipid and cholesterol excretion in feces. The plasma lipoprotein fraction, separated by agarose gel electrophoresis, indicated that P. salmoneostramineus significantly reduced plasma β and pre-β-lipoprotein, while it increased α-lipoprotein. A histological study of liver tissues by conventional hematoxylin-eosin and oil red O staining showed normal in mushroom feed hypercholesterolemic rat. This study suggests that the P. salmoneostramineus diet supplement provided health benefits by acting on the atherogenic lipid profile in hypercholesterolemic rats.


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