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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

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Growth-Inhibitory and Immunomodulatory Activities of Wild Mushrooms from North-Central British Columbia (Canada)

卷 19, 册 6, 2017, pp. 485-497
DOI: 10.1615/IntJMedMushrooms.v19.i6.10
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摘要

Wild mushrooms, especially from North America, have not been systematically explored for their medicinal properties. Here we report screening for the growth-inhibitory and immunomodulatory activities of 12 species collected from multiple locations in north-central British Columbia, Canada. Mushrooms were characterized using morphology and DNA sequencing, followed by chemical extraction into 4 fractions using 80% ethanol, 50% methanol, water, and 5% sodium hydroxide. Growth-inhibitory, immunostimulatory, and anti-inflammatory activities of 5 mushrooms (Leucocybe connata, Trichaptum abietinum, Hydnellum sp., Gyromitra esculenta, and Hericium coralloides) are reported here, to our knowledge for the first time. Growth-inhibitory effects were assessed using the cytotoxic MTT assay. Immunostimulatory activity was assessed by tumor necrosis factor-α production in Raw 264.7 macrophages, whereas anti-inflammatory activity was assessed based on the inhibition of lipopolysaccharide-induced tumor necrosis factor-α production. The ethanol and aqueous extracts of Hydnellum sp. were potent growth inhibitors, with a half-maximal inhibitory concentration of 0.6 mg/mL. All 5 fungi displayed strong immunostimulatory activity, whereas only L. connata and T. abietinum showed strong anti-inflammatory activity. For the 7 other fungi investigated, which included well-known medicinal species such as Inonotus obliquus, Phellinus igniarius, and Ganoderma applanatum, the remarkable similarities in the biological activities reported here, and by others for specimens collected elsewhere, suggest that mushrooms can produce similar metabolites regardless of their habitat or ecosystem. This is to our knowledge the first study to explore wild mushrooms from British Columbia for biological activities that are relevant to cancer, and the results provide an initial framework for the selection of mushroom species with the potential for discovery of novel anticancer compounds.

对本文的引用
  1. Barad Ankush, Mackedenski Sebastian, Li Wai Ming, Li Xiao Jie, Lim Bryan Chu Chwen, Rashid Faran, Tackaberry Linda E., Massicotte Hugues B., Egger Keith N., Reimer Kerry, Cheung Peter C.K., Lee Chow H., Anti-proliferative activity of a purified polysaccharide isolated from the basidiomycete fungus Paxillus involutus, Carbohydrate Polymers, 181, 2018. Crossref

  2. Javed Sumreen, Li Wai Ming, Zeb Mehreen, Yaqoob Almas, Tackaberry Linda E., Massicotte Hugues B., Egger Keith N., Cheung Peter C.K., Payne Geoffrey W., Lee Chow H., Anti-Inflammatory Activity of the Wild Mushroom, Echinodontium tinctorium, in RAW264.7 Macrophage Cells and Mouse Microcirculation, Molecules, 24, 19, 2019. Crossref

  3. Javed Sumreen, Mitchell Kevin, Sidsworth Danielle, Sellers Stephanie L., Reutens-Hernandez Jennifer, Massicotte Hugues B., Egger Keith N., Lee Chow H., Payne Geoffrey W., Gallyas Ferenc, Inonotus obliquus attenuates histamine-induced microvascular inflammation, PLOS ONE, 14, 8, 2019. Crossref

  4. Yaqoob Almas, Li Wai Ming, Liu Victor, Wang Chuyi, Mackedenski Sebastian, Tackaberry Linda E., Massicotte Hugues B., Egger Keith N., Reimer Kerry, Lee Chow H., Amin A R M Ruhul, Grifolin, neogrifolin and confluentin from the terricolous polypore Albatrellus flettii suppress KRAS expression in human colon cancer cells, PLOS ONE, 15, 5, 2020. Crossref

  5. Zeb Mehreen, Lee Chow H., Medicinal Properties and Bioactive Compounds from Wild Mushrooms Native to North America, Molecules, 26, 2, 2021. Crossref

  6. Lu Yangpeng, Jia Yanan, Xue Zihan, Li Nannan, Liu Junyu, Chen Haixia, Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application, Polymers, 13, 9, 2021. Crossref

  7. Zeb Mehreen, Tackaberry Linda E., Massicotte Hugues B., Egger Keith N., Reimer Kerry, Lu Grace, Heiss Christian, Azadi Parastoo, Lee Chow H., Structural elucidation and immuno-stimulatory activity of a novel polysaccharide containing glucuronic acid from the fungus Echinodontium tinctorium, Carbohydrate Polymers, 258, 2021. Crossref

  8. Shen Dayue, Feng Yating, Zhang Xilan, Liu Jing, Gong Le, Liao Hui, Li Rongshan, Liu Xiang, In Vitro Immunomodulatory Effects of Inonotus obliquus Extracts on Resting M0 Macrophages and LPS-Induced M1 Macrophages, Evidence-Based Complementary and Alternative Medicine, 2022, 2022. Crossref

  9. Lee Hooi Xian, Li Wai Ming, Khatra Jatinder, Xia Zhicheng, Sannikov Oleg, Ling Yun, Zhu Haoxuan, Lee Chow H., Antiproliferative Fatty Acids Isolated from the Polypore Fungus Onnia tomentosa, Journal of Fungi, 8, 11, 2022. Crossref

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