摘要

In terms of pharmacology, chalcones are important compounds that have a wide variety of biological activities: antibacterial, antifungal, antitumor, and anti-inflammatory. Structurally diverse chalcones have mainly been isolated from plants. In the course of screening for anti-methicillin-resistant Staphylococcus aureus (MRSA) activity, we discovered activity in the extract from the culinary-medicinal mushroom species Sparassis crispa and succeeded in isolating two compounds as the active principles from the extracts. Identification of the compounds was performed by the interpretation of nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. As a result, the compounds were identified as already known chalcones, xanthoangelol and 4-hydroxyderricin, which have been isolated from the plant Angelica keiskei. To the best of our knowledge, this is the first report of the isolation of chalcones from the Fungi kingdom, and the result indicates the possibility that S. crispa might be a promising source for the production of chalcones, in addition to the plant Angelica keiskei.