图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushr.v4.i3.50
7 pages

The Influence of Selected Higher Basidiomycetes on the Binding of Lipopolysaccharide to CD14+ Cells and on the Release of Cytokines

Jacqueline Koch
Institute of Pharmaceutical Biology, Ernst-Moritz-Arndt-University of Greifswald, F.-L.-Jahn-Str. 17a, D-17487 Greifswald, Germany
Sabine Witt
Biometec GmbH, W.-Rathenau-Str. 49a; D-17489 Greifswald, Germany
Ulrike Lindequist
Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

ABSTRACT

135 extracts of 22 species of Higher Basidiomycetes were screened for their ability to inhibit binding of FITC-labeled endotoxin (LPS) to CD14+ cells and to influence LPS-induced release of proinflammatory cytokines (IL-1b, IL-6, TNF-a), regulatory cytokines (IL-2, IL-4, IL-10, IFN-g), and the release of reactive oxygen species (ROS). Prescreening studies examined cytotoxic effects and LPS content of the extracts. The dichlormethane, ethanolic, and aqueous extracts of fruiting bodies of the following species were shown to be active in at least one of the test systems: Daedalea quercina, Ganoderma pfeifferi, Heterobasidion annosum, Lacfarius vellereus, Laetiporus sulphurous, Phaeolus schweinizii, Piptoporus betulmus, Pleurotus ostreatus, Polyporus badius, Sparassis crispa, Thelephora terrestris, Trametes versicolor, and Tricholomopsis rutilans. Extracts of the following fungi were not active in the test systems used: A. campestris, Agaricus vaporarius, Ganoderma lipsiense, G. lucidum, Hapalopilus nidulans, Hericium erinaceus, Inonotus obliquus, Kuehneromyces mutabilis, and Meripilus giganteus.


Articles with similar content:

Antioxidant and Immunomodulating Activities of Exo-and Endopolysaccharide Fractions from Submerged Mycelia Cultures of Culinary-Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 3
Karthik Marripudi, Cheang Khoo, Sundar Rao Koyyalamudi, Jong Pil Park, Jin Hee Kim, Sang-Chul Jeong, Chi-Hyun Song, J. Margaret Hughes, Trevor Bailey
Ganoderma lucidum (W.Curt.:Fr.) Lloyd and G. applanatum (Pers.) Pat. (Aphyllophoromycetideae) from Slovenian Habitats: Cultivation, Isolation, and Testing of Active Compounds
International Journal of Medicinal Mushrooms, Vol.6, 2004, issue 1
Irena Zore, Branka Wraber, Jozica Habijanic, Damjan Hodzar, Bojana Boh, Marin Berovic
Medicinal Effects and Utilization of Cordyceps (Fr.) Link (Ascomycetes) and Isaria Fr. (Mitosporic Fungi) Chinese Caterpillar Fungi, "Tochukaso" (Review)
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 3
Takashi Mizuno
Anti-Inflammatory Effects of Extracts from the Medicinal Mushrooms Hypsizygus marmoreus and Pleurotus eryngii (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 6
Jeng-Leun Mau, Yi-Chi Yang, Eric Icheng Lai, Rao-Chi Chien
Role of Two Species of Medicinal Mushrooms from Genus Ganoderma P. Karst. (G. lucidum and G. tsugae; Aphyllophoromycetideae) in Selective Estrogen-Receptor Modulations
International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 1
Jun Gong, Jing Qin, Vivien Wing-Yin Luk, Siu Wai Chiu