图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushr.v8.i4.20
pages 315-320

Immunomodulatory Effects of Ganoderma lucidum (W. Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) on CD4+/CD8+ Tumor Infiltrating Lymphocytes in Breast-Cancer-Bearing Mice

Shafi Mojadadi
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran; and Department of Microbiology & Immunology, School of Medicine, Kerman Medical University, Kerman, Iran
Massoumeh Ebtekar
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran
Zuhair Mohammad Hassan
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran

ABSTRACT

Ganoderma lucidum (Basidiomycetes) has been recognized as an immunomodulatory natural product. This study was performed in order to investigate the effects of G. lucidum polysaccharide (GL-PS) extract on tumor volume and T(CD4+/CD8+) ratio of tumor infiltrating lymphocytes (TILs) in breast cancer bearing mice. Initially, we performed the DTH (delayed type hypersensitivity) test for obtaining the most effective dose of GL-PS extract on induction of cell-mediated immune response. Then, we evaluated the effect of this dose on tumor volume and CD4+/CD8+ T subpopulations that infiltrated into cancerous breast tissue. Results indicated that GL-PS 100 mg/kg/day could effectively increase DTH response against sRBC in BALB/c mice. Furthermore, intraperitoneal injection of this extract in breast cancer bearing mice could increase T-cell infiltration into the tumor. Also, there was a significant increase in the CD4+/CD8+ ratio in tumor infiltrating lymphocytes as well as a decrease in tumor volume. We concluded that GL-PS can exhibit a potent immunomodulatory effect and may be used for potentiation of the immune system against diseases such as cancer and other conditions in which the immune response has been compromised.


Articles with similar content:

Immunomodulatory Activity of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Ling Zhi, Reishi) Polysaccharide Extract on Delayed Type Hypersensitivity
International Journal of Medicinal Mushrooms, Vol.8, 2006, issue 1
Zuhair Mohammad Hassan, Shafi Mojadadi, Massoumeh Ebtekar
Lutein Inhibits Cell Growth and Activates Apoptosis via the PI3K/AKT/mTOR Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 4
Wen-long Zhang, Yuan-Song Bai, Zhang-zhen Shi, Dan Cong, Ya-nan Zhao
Combination Therapy of Transplanted Meth-A Fibrosarcoma in BALB/c Mice with Protein-Bound Polysaccharide EA6 Isolated from Enokitake Mushroom Flammulina velutipes (W.Curt.:Fr.)Singer and Surgical Excision
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 1&2
Tetsuro Ikekawa, Hirofumi Maruyama
28-Day Oral Safety Evaluation of Extracellular Polysaccharopeptides Produced in Submerged Culture from the Turkey Tail Medicinal Mushroom Trametes versicolor (L.:Fr.) Pilát LH-1 in Mice
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 3
Fang-Yi Lin, Ju-Fang Teng, Chun-Hong Lai, Po-Wen Yang, Tai-Hao Hsu, Hui-Chen Lo
Immune-Stimulating Effects of Mycoleptodonoides aitchisonii (Agaricomycetes) Water Extract via TNF-α and IFN-γ
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 9
Hong De Xu, Deuk-Sil Oh, Seung-Kil Lim, Seung-Sik Cho, Dae-Hun Park, Soon-Young Lee