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神经生物学评论综述™

ISSN 打印: 0892-0915
ISSN 在线: 2375-0014

Archives: Volume 10, 1996 to Volume 20, 2008

神经生物学评论综述™

DOI: 10.1615/CritRevNeurobiol.v14.i1.40
20 pages

Ethanol and NMDA Receptor Signaling

John J. Woodward
Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, P.O. Box 980524 MCV Station, Richmond, Virginia, 23298

ABSTRACT

NMDA receptors are a multi-subunit family of ionotropic receptors activated by the neurotransmitter glutamate. Localized primarily postsynaptically in neurons, they play an important role in mediating excitatory synaptic neurotransmission and are implicated in a wide variety of important calcium-dependent neuronal processes. Experimental animals expressing mutant forms of NMDA subunits display abnormal behaviors and locomotor and cognitive impairments. Over the last 10 years, a wealth of studies has indicated that NMDA receptors are an important site of action for ethanol in the brain. The effects of acute ethanol on NMDA receptor function is discussed herein, with particular focus on efforts to define a molecular site of action of ethanol on the receptor. While it is dear that the ethanol sensitivity of NMDA receptors is influenced by subunit composition, it is also apparent that posttranslational factors such as phosphorylation and protein-protein interactions are important in modulating this sensitivity.