每年出版 3 期
ISSN 打印: 0892-0915
ISSN 在线: 2375-0014
Dopamine Reuptake by Norepinephrine Neurons: Exception or Rule?
摘要
Dopamine reuptake by norepinephrine terminals can occur in brain areas such as the prefrontal cortex, the nucleus accumbens shell, and the bed nucleus of stria terminalis that are innervated, although unevenly, by both dopamine and norepinephrine neurons. Therefore the antidepressants that bind selectively the norepinephrine transporter might produce their therapeutic effect by raising the extracellular concentration of dopamine besides that of norepinephrine. Moreover, cocaine can be reinforcing even in knock-out mice for the dopamine transporter because it might raise synaptic dopamine in the nucleus accumbens shell by preventing its uptake by the norepinephrine transporter, an effect that could take place even in wild animals. Recently, it has also been suggested that dopamine can be co-released with norepinephrine by norepinephrine neurons, although it is not clear whether this feature might be related to a previous nonspecific uptake of dopamine by the norepinephrine transporter. In this review we discuss the potential role of the nonspecific uptake of dopamine by norepinephrine transporter in the mechanism of action of drugs of abuse, antipsychotics, and antidepressants.
-
Elsworth John D, Jentsch J David, Morrow Bret A, Redmond D Eugene, Roth Robert H, Clozapine Normalizes Prefrontal Cortex Dopamine Transmission in Monkeys Subchronically Exposed to Phencyclidine, Neuropsychopharmacology, 33, 3, 2008. Crossref
-
Pani Pier Paolo, Trogu Emanuela, Amato Laura, Davoli Marina, Antidepressants for the treatment of depression in alcohol dependent individuals, Cochrane Database of Systematic Reviews, 2010. Crossref
-
Pani Pier Paolo, Vacca Rosangela, Trogu Emanuela, Amato Laura, Davoli Marina, Pani Pier Paolo, Pharmacological treatment for depression in opioid dependence, in Cochrane Database of Systematic Reviews, 2010. Crossref
-
Sora Ichiro, Igari Moe, Yamamoto Hideko, Ikeda Kazutaka, Monoamine transporter as a target molecule for psychostimulants, Folia Pharmacologica Japonica, 130, 6, 2007. Crossref
-
Gilsbach R., Faron-Gorecka A., Rogoz Z., Bruss M., Caron M. G., Dziedzicka-Wasylewska M., Bonisch H., Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors, Journal of Neurochemistry, 96, 4, 2006. Crossref
-
Easton Neil, Shah Yasmene B., Marshall Fiona H., Fone Kevin C., Marsden Charles A., Guanfacine produces differential effects in frontal cortex compared with striatum: assessed by phMRI BOLD contrast, Psychopharmacology, 189, 3, 2006. Crossref
-
Schank Jesse R, Ventura Rossella, Puglisi-Allegra Stefano, Alcaro Antonio, Cole Charlene D, Liles L Cameron, Seeman Philip, Weinshenker David, Dopamine β-Hydroxylase Knockout Mice have Alterations in Dopamine Signaling and are Hypersensitive to Cocaine, Neuropsychopharmacology, 31, 10, 2006. Crossref
-
Pani Pier Paolo, Vacca Rosangela, Trogu Emanuela, Amato Laura, Davoli Marina, Pharmacological treatment for depression during opioid agonist treatment for opioid dependence, Cochrane Database of Systematic Reviews, 2010. Crossref
-
Wersinger Christophe, Jeannotte Alexis, Sidhu Anita, Attenuation of the norepinephrine transporter activity and trafficking via interactions with α-synuclein, European Journal of Neuroscience, 24, 11, 2006. Crossref
-
El Mansari Mostafa, Guiard Bruno P., Chernoloz Olga, Ghanbari Ramez, Katz Noam, Blier Pierre, Relevance of Norepinephrine-Dopamine Interactions in the Treatment of Major Depressive Disorder, CNS Neuroscience & Therapeutics, 16, 3, 2010. Crossref
-
Smith Rachel J., Aston-Jones Gary, Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence, Brain Structure and Function, 213, 1-2, 2008. Crossref
-
Weinshenker David, Schroeder Jason P, There and Back Again: A Tale of Norepinephrine and Drug Addiction, Neuropsychopharmacology, 32, 7, 2007. Crossref
-
Robinson Emma S. J., Blockade of noradrenaline re-uptake sites improves accuracy and impulse control in rats performing a five-choice serial reaction time tasks, Psychopharmacology, 219, 2, 2012. Crossref
-
Engleman Eric A., Ingraham Cynthia M., McBride William J., Lumeng Lawrence, Murphy James M., Extracellular dopamine levels are lower in the medial prefrontal cortex of alcohol-preferring rats compared to Wistar rats, Alcohol, 38, 1, 2006. Crossref
-
Gilbert François, Morissette Marc, St-Hilaire Michel, Paquet Brigitte, Rouillard Claude, Di Paolo Thérèse, Lévesque Daniel, Nur77 Gene Knockout Alters Dopamine Neuron Biochemical Activity and Dopamine Turnover, Biological Psychiatry, 60, 6, 2006. Crossref
-
Porcelli S., Drago A., Fabbri C., Serretti A., Mechanisms of antidepressant action: An integrated dopaminergic perspective, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35, 7, 2011. Crossref
-
Logan Jean, Ding Yu-Shin, Lin Kuo-Shyan, Pareto Deborah, Fowler Joanna, Biegon Anat, Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region, Nuclear Medicine and Biology, 32, 5, 2005. Crossref
-
Daws Lynette C., Unfaithful neurotransmitter transporters: Focus on serotonin uptake and implications for antidepressant efficacy, Pharmacology & Therapeutics, 121, 1, 2009. Crossref
-
Wedemeyer Carolina, Goutman Juan D., Avale María E., Franchini Lucía F., Rubinstein Marcelo, Calvo Daniel J., Functional activation by central monoamines of human dopamine D4 receptor polymorphic variants coupled to GIRK channels in Xenopus oocytes, European Journal of Pharmacology, 562, 3, 2007. Crossref
-
Millan Mark J., Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application, Pharmacology & Therapeutics, 110, 2, 2006. Crossref
-
Haenisch Britta, Bönisch Heinz, Depression and antidepressants: Insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters, Pharmacology & Therapeutics, 129, 3, 2011. Crossref
-
Baladi Michelle G., Daws Lynette C., France Charles P., You are what you eat: Influence of type and amount of food consumed on central dopamine systems and the behavioral effects of direct- and indirect-acting dopamine receptor agonists, Neuropharmacology, 63, 1, 2012. Crossref
-
Geng Joy J., Soosman Steffan, Sun Yile, DiQuattro Nicholas E., Stankevitch Beth, Minzenberg Michael J., A Match Made by Modafinil: Probability Matching in Choice Decisions and Spatial Attention, Journal of Cognitive Neuroscience, 25, 5, 2013. Crossref
-
Kennett A., Heal D. J., Wonnacott S., Pharmacological Differences Between Rat Frontal Cortex and Hippocampus in the Nicotinic Modulation of Noradrenaline Release Implicate Distinct Receptor Subtypes, Nicotine & Tobacco Research, 14, 11, 2012. Crossref
-
Yamauchi Miki, Imanishi Taiichiro, Koyama Tsukasa, A combination of mirtazapine and milnacipran augments the extracellular levels of monoamines in the rat brain, Neuropharmacology, 62, 7, 2012. Crossref
-
Rothmond Debora A, Weickert Cynthia S, Webster Maree J, Developmental changes in human dopamine neurotransmission: cortical receptors and terminators, BMC Neuroscience, 13, 1, 2012. Crossref
-
Millan M.J., Panayi F., Rivet J.M., Cara B. Di, Cistarelli L., Billiras R., Girardon S., Gobert A., Chapter 6.1 The role of microdialysis in drug discovery: focus on antipsychotic agents, in Handbook of Microdialysis - Methods, Applications and Perspectives, 16, 2006. Crossref
-
Jacobsen J.P.R., Rodriguiz R.M., Mørk A., Wetsel W.C., Monoaminergic dysregulation in glutathione-deficient mice: Possible relevance to schizophrenia?, Neuroscience, 132, 4, 2005. Crossref
-
Bröer Stefan, Gether Ulrik, The solute carrier 6 family of transporters, British Journal of Pharmacology, 167, 2, 2012. Crossref
-
Tejeda H. A., Shippenberg T. S., Henriksson R., The dynorphin/κ-opioid receptor system and its role in psychiatric disorders, Cellular and Molecular Life Sciences, 69, 6, 2012. Crossref
-
Bari A., Robbins T. W., Noradrenergic versus dopaminergic modulation of impulsivity, attention and monitoring behaviour in rats performing the stop-signal task, Psychopharmacology, 230, 1, 2013. Crossref
-
Shang Chi-Yung, Chiang Huey-Ling, Gau Susan Shur-Fen, A haplotype of the norepinephrine transporter gene (SLC6A2) is associated with visual memory in attention-deficit/hyperactivity disorder, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 58, 2015. Crossref
-
Sesack Susan R., Prefrontal Cortical Dopamine Transmission, in The Synapse, 2014. Crossref
-
Liu Yia-Ping, Huang Teng-Shun, Tung Che-Se, Lin Chen-Cheng, Effects of atomoxetine on attention and impulsivity in the five-choice serial reaction time task in rats with lesions of dorsal noradrenergic ascending bundle, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 56, 2015. Crossref
-
Hache Guillaume, Coudore François, Gardier Alain M., Guiard Bruno P., Monoaminergic Antidepressants in the Relief of Pain: Potential Therapeutic Utility of Triple Reuptake Inhibitors (TRIs), Pharmaceuticals, 4, 2, 2011. Crossref
-
Baladi M. G., Horton R. E., Owens W. A., Daws L. C., France C. P., Eating High Fat Chow Decreases Dopamine Clearance in Adolescent and Adult Male Rats but Selectively Enhances the Locomotor Stimulating Effects of Cocaine in Adolescents, International Journal of Neuropsychopharmacology, 18, 7, 2015. Crossref
-
Tamilselvan Thangavel, Siddique Saiful Alom, Vishnupriya Manikannan, Sindhu Ganapathy, Balamurugan Elumalai, Behavioral and neurochemical evaluation of ethanol on olanzapine treated methylphenidate induced manic like behaviors in swiss albino mice, Beni-Suef University Journal of Basic and Applied Sciences, 6, 1, 2017. Crossref
-
Ohmura Yu, Tsutsui-Kimura Iku, Yoshioka Mitsuhiro, Impulsive Behavior and Nicotinic Acetylcholine Receptors, Journal of Pharmacological Sciences, 118, 4, 2012. Crossref
-
Agabio Roberta, Trogu Emanuela, Pani Pier Paolo, Antidepressants for the treatment of people with co-occurring depression and alcohol dependence, Cochrane Database of Systematic Reviews, 2018, 4, 2018. Crossref
-
Klein Marianne O., Battagello Daniella S., Cardoso Ariel R., Hauser David N., Bittencourt Jackson C., Correa Ricardo G., Dopamine: Functions, Signaling, and Association with Neurological Diseases, Cellular and Molecular Neurobiology, 39, 1, 2019. Crossref
-
Bravo Lidia, Llorca-Torralba Meritxell, Berrocoso Esther, Micó Juan Antonio, Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain, Frontiers in Neuroscience, 13, 2019. Crossref
-
Bocharova O. A., Bocharov E. V., Kucheryanu V. G., Karpova R. V., Dopaminergic system: stress, depression, cancer (part 1), Russian Journal of Biotherapy, 18, 3, 2019. Crossref
-
Wang Ching-I A., Shaikh Nausad H., Ramu Soumya, Lewis Richard J., A Second Extracellular Site Is Required for Norepinephrine Transport by the Human Norepinephrine Transporter, Molecular Pharmacology, 82, 5, 2012. Crossref
-
Cherner Mariana, Watson Caitlin W.-M., Saloner Rowan, Halpin Laura E., Minassian Arpi, Murray Sarah S., Vaida Florin, Bousman Chad, Everall Ian, Adverse effect of catechol-O-methyltransferase (COMT) Val158Met met/met genotype in methamphetamine-related executive dysfunction, Addictive Behaviors, 98, 2019. Crossref
-
Bönisch H., Brüss M., The Norepinephrine Transporter in Physiology and Disease, in Neurotransmitter Transporters, 175, 2006. Crossref
-
Baladi Michelle G., Forster Michael J., Gatch Michael B., Mailman Richard B., Hyman Danielle L., Carter Lawrence P., Janowsky Aaron, Characterization of the Neurochemical and Behavioral Effects of Solriamfetol (JZP-110), a Selective Dopamine and Norepinephrine Reuptake Inhibitor, Journal of Pharmacology and Experimental Therapeutics, 366, 2, 2018. Crossref
-
Guiard Bruno P., El Mansari Mostafa, Blier Pierre, Cross-Talk between Dopaminergic and Noradrenergic Systems in the Rat Ventral Tegmental Area, Locus Ceruleus, and Dorsal Hippocampus, Molecular Pharmacology, 74, 5, 2008. Crossref
-
Бочаров Е.В., Кучеряну В.Г., Бочарова О.А., Functional facets of dopaminergic system and cancer. Part 1, ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», 3(), 2017. Crossref
-
Schneider Jay S., Marshall Courtney A., Keibel Lauren, Snyder Nathaniel W., Hill Michael P., Brotchie Jonathan M., Johnston Tom H., Waterhouse Barry D., Kortagere Sandhya, A novel dopamine D3R agonist SK609 with norepinephrine transporter inhibition promotes improvement in cognitive task performance in rodent and non-human primate models of Parkinson's disease, Experimental Neurology, 335, 2021. Crossref
-
Navailles S., Lagière M., Contini A., De Deurwaerdère P., Multisite Intracerebral Microdialysis to Study the Mechanism of L-DOPA Induced Dopamine and Serotonin Release in the Parkinsonian Brain, ACS Chemical Neuroscience, 4, 5, 2013. Crossref
-
Bayassi-Jakowicka Martyna, Lietzau Grazyna, Czuba Ewelina, Steliga Aleksandra, Waśkow Monika, Kowiański Przemysław, Neuroplasticity and Multilevel System of Connections Determine the Integrative Role of Nucleus Accumbens in the Brain Reward System, International Journal of Molecular Sciences, 22, 18, 2021. Crossref
-
Chang Jung-Chi, Lin Hsiang-Yuan, Lv Jinglei, Tseng Wen-Yih Issac, Gau Susan Shur-Fen, Regional brain volume predicts response to methylphenidate treatment in individuals with ADHD, BMC Psychiatry, 21, 1, 2021. Crossref
-
Moriguchi Sho, Kimura Yasuyuki, Ichise Masanori, Arakawa Ryosuke, Takano Harumasa, Seki Chie, Ikoma Yoko, Takahata Keisuke, Nagashima Tomohisa, Yamada Makiko, Mimura Masaru, Suhara Tetsuya, PET Quantification of the Norepinephrine Transporter in Human Brain with (S,S)-18F-FMeNER-D2, Journal of Nuclear Medicine, 58, 7, 2017. Crossref
-
Aston-Jones Gary, Cohen Jonathan D., AN INTEGRATIVE THEORY OF LOCUS COERULEUS-NOREPINEPHRINE FUNCTION: Adaptive Gain and Optimal Performance, Annual Review of Neuroscience, 28, 1, 2005. Crossref
-
Grund Thorsten, Lehmann Konrad, Bock Nathalie, Rothenberger Aribert, Teuchert-Noodt Gertraud, Influence of methylphenidate on brain development – an update of recent animal experiments, Behavioral and Brain Functions, 2, 1, 2006. Crossref
-
Brummelte Susanne, Grund Thorsten, Moll Gunther H, Teuchert-Noodt Gertraud, Dawirs Ralph R, Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils, Journal of Negative Results in BioMedicine, 7, 1, 2008. Crossref
-
Shang Chi-Yung, Lin Hsiang-Yuan, Gau Susan Shur-Fen, The norepinephrine transporter gene modulates intrinsic brain activity, visual memory, and visual attention in children with attention-deficit/hyperactivity disorder, Molecular Psychiatry, 26, 8, 2021. Crossref
-
Yu Yang, Miller Renee, Groth Susan W., A literature review of dopamine in binge eating, Journal of Eating Disorders, 10, 1, 2022. Crossref
-
Mannangatti Padmanabhan, Ragu Varman Durairaj, Ramamoorthy Sammanda, Jayanthi Lankupalle D., Neurokinin-1 Antagonism Distinguishes the Role of Norepinephrine Transporter from Dopamine Transporter in Mediating Amphetamine Behaviors, Pharmacology, 106, 11-12, 2021. Crossref
-
Frau Roberto, Devoto Paola, Aroni Sonia, Saba Pierluigi, Sagheddu Claudia, Siddi Carlotta, Santoni Michele, Carli Marco, Gessa Gian Luigi, The potent α2-adrenoceptor antagonist RS 79948 also inhibits dopamine D2 -receptors: Comparison with atipamezole and raclopride, Neuropharmacology, 217, 2022. Crossref