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神经生物学评论综述™
SJR: 0.121

ISSN 打印: 0892-0915
ISSN 在线: 2375-0014

Archives: Volume 10, 1996 to Volume 20, 2008

神经生物学评论综述™

DOI: 10.1615/CritRevNeurobiol.v16.i12.160
pages 147-158

Cannabinoids and Reward: Interactions with the Opioid System

Liana Fattore
Institute of Neuroscience, National Research Council CNR, Section of Cagliari; and Centre of Excellence "Neurobiology of Dependence," Cittadella Universitaria di Monserrato, University of Cagliari, Italy
Gregorio Cossu
Department of Neuroscience and Centre of Excellence "Neurobiology of Dependence," Cittadella Universitaria di Monserrato, University of Cagliari, Italy
Maria S. Spano
Department of Neuroscience and Centre of Excellence "Neurobiology of Dependence," Cittadella Universitaria di Monserrato, University of Cagliari, Italy
Serena Deiana
Department of Neuroscience and Centre of Excellence "Neurobiology of Dependence," Cittadella Universitaria di Monserrato, University of Cagliari, Italy
Paola Fadda
Department of Neuroscience and 3 Centre of Excellence "Neurobiology of Dependence," Cittadella Universitaria di Monserrato, University of Cagliari, Italy
Maria Scherma
Department of Neuroscience and Centre of Excellence "Neurobiology of Dependence," Cittadella Universitaria di Monserrato, University of Cagliari, Italy
Walter Fratta
Institute of Neuroscience, National Research Council CNR, Section of Cagliari; and Department of Neuroscience and Centre of Excellence "Neurobiology of Dependence," Cittadella Universitaria di Monserrato, University of Cagliari, Italy

ABSTRACT

There is currently substantial evidence that Cannabis sativa derivates act on brain reward in a way very similar to other drugs of abuse and exert numerous pharmacological effects through their interaction with various neurotransmitters and neuromodulators. Among them, the endogenous opioids seem to play an important role in modulating the addictive properties of cannabinoids. Given the plethora of research activity on such a topic, this brief review is necessarily focused on cannabinoid/opioid interaction in reward-related events and restricted to the recent literature. Recent findings from our and other laboratories concerning cannabinoid reinforcing effects as revealed by behavioral animal models of addiction are here summarized. Evidence is then provided demonstrating a functional cross-talk between the cannabinoid and opioid systems in the mutual modulation of the addictive behavior; accordingly, very recent data from transgenic mice lacking either the cannabinoid CB1 or opioid receptors are also presented. Finally, the role of the endogenous cannabinoid system in relapse to opioids is investigated by means of extinction/reinstatement animal models following a period, even prolonged, of drug abstinence. Altogether, the reviewed studies provided a better understanding of the neurobiological mechanisms involved in cannabinoid actions and revealed a bidirectional interaction between the endogenous cannabinoid and opioid systems in reward that extends to central mechanisms underlying relapsing phenomena. Challenges for the future involve elucidation of the neuroanatomical substrates of cannabinoids action, even in light of the therapeutic potential of these compounds.


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