每年出版 3 期
ISSN 打印: 0892-0915
ISSN 在线: 2375-0014
Molecular Biology of Muscarinic Acetylcholine Receptors
摘要
Following the molecular cloning of five distinct muscarinic acetylcholine receptor (mAChR) genes, the last decade has witnessed an explosion of new knowledge about how mAChRs function at a molecular level. These studies have been greatly facilitated by the molecular characterization of the many components of the signal transduction pathways activated upon mAChR stimulation. Molecular genetic and biochemical approaches have considerably advanced our knowledge about how mAChRs are assembled, how they bind ligands, and which structural elements on the mAChRs are critical for G protein coupling. In addition, the molecular mechanisms involved in the regulation of mAChR activity (including mAChR sequestration, down-regulation, and phosphorylation) have been explored in great detail. Since the mAChRs are typical members of the superfamily of G protein-coupled receptors, the information gathered with this class of receptors should be of broad general relevance.
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He Nan, Mao Li-Min, Sturich Adrian W., Jin Dao-Zhong, Wang John Q., Inhibition of basal and amphetamine-stimulated extracellular signal-regulated kinase (ERK) phosphorylation in the rat forebrain by muscarinic acetylcholine M4 receptors, Brain Research, 1688, 2018. Crossref
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Rhoden Alexandra, Speiser Jakob, Geertz Birgit, Uebeler June, Schmidt Kjestine, de Wit Cor, Eschenhagen Thomas, Preserved cardiovascular homeostasis despite blunted acetylcholine‐induced dilation in mice with endothelial muscarinic M3 receptor deletion, Acta Physiologica, 226, 1, 2019. Crossref
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Jakubı́k Jan, Tuček Stanislav, El-Fakahany Esam E., Allosteric Modulation by Persistent Binding of Xanomeline of the Interaction of Competitive Ligands with the M1 Muscarinic Acetylcholine Receptor, Journal of Pharmacology and Experimental Therapeutics, 301, 3, 2002. Crossref
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Shafer Shulamith H., Williams Carol L., Elevated Rac1 Activity Changes the M3Muscarinic Acetylcholine Receptor-Mediated Inhibition of Proliferation to Induction of Cell Death, Molecular Pharmacology, 65, 5, 2004. Crossref
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Kostenis Evi, Conklin Bruce R., Wess Jürgen, Molecular Basis of Receptor/G Protein Coupling Selectivity Studied by Coexpression of Wild Type and Mutant m2 Muscarinic Receptors with Mutant Gαq Subunits, Biochemistry, 36, 6, 1997. Crossref
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Zhao Xue, Fu Xiaoying, Yuan Xinyi, Shayiranbieke Aerduosi, Xu Ru, Cao Fang, Ren Jianping, Liang Qi, Zhao Xinfeng, Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor, Journal of Chromatography A, 1653, 2021. Crossref
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Tanahashi Yasuyuki, Komori Seiichi, Matsuyama Hayato, Kitazawa Takio, Unno Toshihiro, Functions of Muscarinic Receptor Subtypes in Gastrointestinal Smooth Muscle: A Review of Studies with Receptor-Knockout Mice, International Journal of Molecular Sciences, 22, 2, 2021. Crossref
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Skaddan Marc B., Kilbourn Michael R., Snyder Scott E., Sherman Phil S., Desmond Tim J., Frey Kirk A., Synthesis, 18F-Labeling, and Biological Evaluation of Piperidyl and Pyrrolidyl Benzilates as in Vivo Ligands for Muscarinic Acetylcholine Receptors, Journal of Medicinal Chemistry, 43, 23, 2000. Crossref
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Shiga Yousuke, Minami Kouichiro, Shiraishi Munehiro, Uezono Yasuhito, Murasaki Osamu, Kaibara Muneshige, Shigematsu Akio, The Inhibitory Effects of Tramadol on Muscarinic Receptor-Induced Responses in Xenopus Oocytes Expressing Cloned M3 Receptors, Anesthesia & Analgesia, 95, 5, 2002. Crossref
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Gautam Dinesh, Jeon Jongrye, Starost Matthew F., Han Sung-Jun, Hamdan Fadi F., Cui Yinghong, Parlow Albert F., Gavrilova Oksana, Szalayova Ildiko, Mezey Eva, Wess Jürgen, Neuronal M 3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth , Proceedings of the National Academy of Sciences, 106, 15, 2009. Crossref
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Rinaldo Lorenzo, Hansel Christian, Muscarinic acetylcholine receptor activation blocks long-term potentiation at cerebellar parallel fiber–Purkinje cell synapses via cannabinoid signaling, Proceedings of the National Academy of Sciences, 110, 27, 2013. Crossref
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Song Pingfang, Sekhon Harmanjatinder S., Lu Allison, Arredondo Juan, Sauer David, Gravett Courtney, Mark Gregory P., Grando Sergei A., Spindel Eliot R., M3 Muscarinic Receptor Antagonists Inhibit Small Cell Lung Carcinoma Growth and Mitogen-Activated Protein Kinase Phosphorylation Induced by Acetylcholine Secretion, Cancer Research, 67, 8, 2007. Crossref
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Han Sung-Jun, Hamdan Fadi F., Kim Soo-Kyung, Jacobson Kenneth A., Brichta Lars, Bloodworth Lanh M., Li Jian H., Wess Jürgen, Pronounced Conformational Changes following Agonist Activation of the M3 Muscarinic Acetylcholine Receptor, Journal of Biological Chemistry, 280, 26, 2005. Crossref
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Pavlov Valentin A., Ochani Mahendar, Gallowitsch-Puerta Margot, Ochani Kanta, Huston Jared M., Czura Christopher J., Al-Abed Yousef, Tracey Kevin J., Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia, Proceedings of the National Academy of Sciences, 103, 13, 2006. Crossref
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Duttaroy Alokesh, Zimliki Charles L., Gautam Dinesh, Cui Yinghong, Mears David, Wess Jürgen, Muscarinic Stimulation of Pancreatic Insulin and Glucagon Release Is Abolished in M3 Muscarinic Acetylcholine Receptor–Deficient Mice, Diabetes, 53, 7, 2004. Crossref
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Li Bo, Nowak Nicola M., Kim Soo-Kyung, Jacobson Kenneth A., Bagheri Ali, Schmidt Clarice, Wess Jürgen, Random Mutagenesis of the M3 Muscarinic Acetylcholine Receptor Expressed in Yeast, Journal of Biological Chemistry, 280, 7, 2005. Crossref
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Liu Hongtao, Hofmann Josefa, Fish Inbar, Schaake Benjamin, Eitel Katrin, Bartuschat Amelie, Kaindl Jonas, Rampp Hannelore, Banerjee Ashutosh, Hübner Harald, Clark Mary J., Vincent Sandra G., Fisher John T., Heinrich Markus R., Hirata Kunio, Liu Xiangyu, Sunahara Roger K., Shoichet Brian K., Kobilka Brian K., Gmeiner Peter, Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists, Proceedings of the National Academy of Sciences, 115, 47, 2018. Crossref
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Takizuka Atsushi, Minami Kouichiro, Uezono Yasuhito, Horishita Takafumi, Yokoyama Toru, Shiraishi Munehiro, Sakurai Takeshi, Shigematsu Akio, Ueta Yoichi, Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenopus oocytes and muscarine-induced intracellular Ca2+ elevation in cultured rat dorsal root ganglia cells, Naunyn-Schmiedeberg's Archives of Pharmacology, 375, 5, 2007. Crossref
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Basile Anthony S., Fedorova Irina, Zapata Agustin, Liu Xiaoguang, Shippenberg Toni, Duttaroy Alokesh, Yamada Masahisa, Wess Jürgen, Deletion of the M 5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia , Proceedings of the National Academy of Sciences, 99, 17, 2002. Crossref
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Gerber David J., Sotnikova Tatyana D., Gainetdinov Raul R., Huang Shu Ying, Caron Marc G., Tonegawa Susumu, Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice, Proceedings of the National Academy of Sciences, 98, 26, 2001. Crossref
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Hansen Gesine, Jin S.-L. Catherine, Umetsu Dale T., Conti Marco, Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D, Proceedings of the National Academy of Sciences, 97, 12, 2000. Crossref
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Gomeza Jesus, Shannon Harlan, Kostenis Evi, Felder Christian, Zhang Lu, Brodkin Jesse, Grinberg Alexander, Sheng Hui, Wess Jürgen, Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice, Proceedings of the National Academy of Sciences, 96, 4, 1999. Crossref
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Chen Shao-Rui, Chen Hong, Yuan Wei-Xiu, Wess Jürgen, Pan Hui-Lin, Dynamic Control of Glutamatergic Synaptic Input in the Spinal Cord by Muscarinic Receptor Subtypes Defined Using Knockout Mice, Journal of Biological Chemistry, 285, 52, 2010. Crossref
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Scarselli Marco, Li Bo, Kim Soo-Kyung, Wess Jürgen, Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation, Journal of Biological Chemistry, 282, 10, 2007. Crossref
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Yamada Masahisa, Lamping Kathryn G., Duttaroy Alokesh, Zhang Weilie, Cui Yinghong, Bymaster Frank P., McKinzie David L., Felder Christian C., Deng Chu-Xia, Faraci Frank M., Wess Jürgen, Cholinergic dilation of cerebral blood vessels is abolished in M 5 muscarinic acetylcholine receptor knockout mice , Proceedings of the National Academy of Sciences, 98, 24, 2001. Crossref
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Das Krishnendu, Gabrielli Luca, Prins Leonard J., Chemically Fueled Self‐Assembly in Biology and Chemistry, Angewandte Chemie International Edition, 60, 37, 2021. Crossref
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Schmidt Clarice, Li Bo, Bloodworth Lanh, Erlenbach Isolde, Zeng Fu-Yue, Wess Jürgen, Random Mutagenesis of the M3 Muscarinic Acetylcholine Receptor Expressed in Yeast, Journal of Biological Chemistry, 278, 32, 2003. Crossref
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Das Krishnendu, Gabrielli Luca, Prins Leonard J., Chemically Fueled Self‐Assembly in Biology and Chemistry, Angewandte Chemie, 133, 37, 2021. Crossref
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Wess Jürgen, Muscarinic Receptors, in Encyclopedia of Molecular Pharmacology, 2021. Crossref
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Thompson Karen J., Tobin Andrew B., Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer's disease?, Cellular Signalling, 70, 2020. Crossref
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McClatchy Daniel B., Knudsen Charlotte R., Clark Brian F., Kahn Richard A., Hall Randy A., Levey Allan I., Novel Interaction between the M4 Muscarinic Acetylcholine Receptor and Elongation Factor 1A2, Journal of Biological Chemistry, 277, 32, 2002. Crossref
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Tzavara E T, Bymaster F P, Felder C C, Wade M, Gomeza J, Wess J, McKinzie D L, Nomikos G G, Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice, Molecular Psychiatry, 8, 7, 2003. Crossref
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Poulsen Frantz Rom, Jahnsen Henrik, Blaabjerg Morten, Zimmer Jens, Pilocarpine-induced seizure-like activity with increased BNDF and neuropeptide Y expression in organotypic hippocampal slice cultures, Brain Research, 950, 1-2, 2002. Crossref
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Ruiz de Azua Inigo, Scarselli Marco, Rosemond Erica, Gautam Dinesh, Jou William, Gavrilova Oksana, Ebert Philip J., Levitt Pat, Wess Jürgen, RGS4 is a negative regulator of insulin release from pancreatic β-cells in vitro and in vivo, Proceedings of the National Academy of Sciences, 107, 17, 2010. Crossref
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Gomeza Jesus, Zhang Lu, Kostenis Evi, Felder Christian, Bymaster Frank, Brodkin Jesse, Shannon Harlan, Xia Bing, Deng Chu-xia, Wess Jürgen, Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M 4 muscarinic acetylcholine receptor knockout mice , Proceedings of the National Academy of Sciences, 96, 18, 1999. Crossref
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Li Jian Hua, Han Sung-Jun, Hamdan Fadi F., Kim Soo-Kyung, Jacobson Kenneth A., Bloodworth Lanh M., Zhang Xiaohong, Wess Jürgen, Distinct Structural Changes in a G Protein-coupled Receptor Caused by Different Classes of Agonist Ligands, Journal of Biological Chemistry, 282, 36, 2007. Crossref
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Lin Kedan, Wang Danxin, Sadée Wolfgang, Serum Response Factor Activation by Muscarinic Receptors via RhoA, Journal of Biological Chemistry, 277, 43, 2002. Crossref
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Guerra Marcy L., Wauson Eric M., McGlynn Kathleen, Cobb Melanie H., Muscarinic Control of MIN6 Pancreatic β Cells Is Enhanced by Impaired Amino Acid Signaling, Journal of Biological Chemistry, 289, 20, 2014. Crossref
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Qian J, Galitovskiy V, Chernyavsky A I, Marchenko S, Grando S A, Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of naïve CD4 T cells toward the Th1, Th2 and Th17 lineages, Genes & Immunity, 12, 3, 2011. Crossref
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Chen Shao-Rui, Chen Hong, Yuan Wei-Xiu, Wess Jürgen, Pan Hui-Lin, Differential Regulation of Primary Afferent Input to Spinal Cord by Muscarinic Receptor Subtypes Delineated Using Knockout Mice, Journal of Biological Chemistry, 289, 20, 2014. Crossref
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Okoshi Katashi, Nakayama Masaharu, Yan Xinhua, Okoshi Marina P., Schuldt Adam J.T., Marchionni Mark A., Lorell Beverly H., Neuregulins Regulate Cardiac Parasympathetic Activity, Circulation, 110, 6, 2004. Crossref
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Nadler Laurie S., Kumar Geetha, Nathanson Neil M., Identification of a Basolateral Sorting Signal for the M3 Muscarinic Acetylcholine Receptor in Madin-Darby Canine Kidney Cells, Journal of Biological Chemistry, 276, 13, 2001. Crossref
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Billet Arnaud, Luo Yishan, Balghi Haouaria, Hanrahan John W., Role of Tyrosine Phosphorylation in the Muscarinic Activation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), Journal of Biological Chemistry, 288, 30, 2013. Crossref
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Erlenbach Isolde, Wess Jürgen, Molecular Basis of V2 Vasopressin Receptor/GsCoupling Selectivity, Journal of Biological Chemistry, 273, 41, 1998. Crossref
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Jiménez Esperanza, Fornés Amparo, Felipe Raquel, Núñez Enrique, Aragón Carmen, López-Corcuera Beatriz, Calcium-Dependent Regulation of the Neuronal Glycine Transporter GlyT2 by M2 Muscarinic Acetylcholine Receptors, Neurochemical Research, 47, 1, 2022. Crossref
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Nathanson Neil M., A multiplicity of muscarinic mechanisms: Enough signaling pathways to take your breath away, Proceedings of the National Academy of Sciences, 97, 12, 2000. Crossref
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Honda Kenji, Harada Akitsugu, Takano Yukio, Kamiya Hiro-o, Involvement of M3 muscarinic receptors of the spinal cord in formalin-induced nociception in mice, Brain Research, 859, 1, 2000. Crossref
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Wess Jürgen, Eglen Richard M., Gautam Dinesh, Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development, Nature Reviews Drug Discovery, 6, 9, 2007. Crossref
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Hu Jianxin, Hu Kelly, Liu Tong, Stern Matthew K., Mistry Rajendra, Challiss R.A.John, Costanzi Stefano, Wess Jürgen, Novel Structural and Functional Insights into M3 Muscarinic Receptor Dimer/Oligomer Formation, Journal of Biological Chemistry, 288, 48, 2013. Crossref
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Han Sung-Jun, Hamdan Fadi F., Kim Soo-Kyung, Jacobson Kenneth A., Bloodworth Lanh M., Li Bo, Wess Jürgen, Identification of an Agonist-induced Conformational Change Occurring Adjacent to the Ligand-binding Pocket of the M3 Muscarinic Acetylcholine Receptor, Journal of Biological Chemistry, 280, 41, 2005. Crossref
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Yang Jun-Min, Yang Xiao-Yu, Wan Jian-Hua, Multiple roles for cholinergic signaling in pancreatic diseases, World Journal of Gastroenterology, 28, 25, 2022. Crossref
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Calaf Gloria M., Role of organophosphorous pesticides and acetylcholine in breast carcinogenesis, Seminars in Cancer Biology, 76, 2021. Crossref
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Pfeiffer Julia B. R., Mevissen Meike, Steiner Adrian, Portier Christopher J., Meylan Mireille, In vitro effects of bethanechol on specimens of intestinal smooth muscle obtained from the duodenum and jejunum of healthy dairy cows, American Journal of Veterinary Research, 68, 3, 2007. Crossref
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Bai Yueqi, Wang Luozheng, Organophosphate-induced inhibition of acetylcholinesterase, oxidative stress and neuroinflammation, Highlights in Science, Engineering and Technology, 8, 2022. Crossref
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Golime RamaRao, Singh Naveen, Molecular interactions of chemical warfare agents with biological systems, in Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects, 2023. Crossref
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Naznin Farhana, Waise T. M. Zaved, Fernyhough Paul, Antagonism of the Muscarinic Acetylcholine Type 1 Receptor Enhances Mitochondrial Membrane Potential and Expression of Respiratory Chain Components via AMPK in Human Neuroblastoma SH-SY5Y Cells and Primary Neurons, Molecular Neurobiology, 59, 11, 2022. Crossref
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Sanders Kenton M., Baker Salah A., Drumm Bernard T., Kurahashi Masaaki, Ca2+ Signaling Is the Basis for Pacemaker Activity and Neurotransduction in Interstitial Cells of the GI Tract, in The Enteric Nervous System II, 1383, 2022. Crossref