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ISSN 打印: 0892-0915

ISSN 在线: 2375-0014

SJR: 0.121

Molecular Biology of Muscarinic Acetylcholine Receptors

卷 10, 册 1, 1996, pp. 69-99
DOI: 10.1615/CritRevNeurobiol.v10.i1.40
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摘要

Following the molecular cloning of five distinct muscarinic acetylcholine receptor (mAChR) genes, the last decade has witnessed an explosion of new knowledge about how mAChRs function at a molecular level. These studies have been greatly facilitated by the molecular characterization of the many components of the signal transduction pathways activated upon mAChR stimulation. Molecular genetic and biochemical approaches have considerably advanced our knowledge about how mAChRs are assembled, how they bind ligands, and which structural elements on the mAChRs are critical for G protein coupling. In addition, the molecular mechanisms involved in the regulation of mAChR activity (including mAChR sequestration, down-regulation, and phosphorylation) have been explored in great detail. Since the mAChRs are typical members of the superfamily of G protein-coupled receptors, the information gathered with this class of receptors should be of broad general relevance.

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  233. He Nan, Mao Li-Min, Sturich Adrian W., Jin Dao-Zhong, Wang John Q., Inhibition of basal and amphetamine-stimulated extracellular signal-regulated kinase (ERK) phosphorylation in the rat forebrain by muscarinic acetylcholine M4 receptors, Brain Research, 1688, 2018. Crossref

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  236. Laspas Panagiotis, Zhutdieva Mayagozel B., Brochhausen Christoph, Musayeva Aytan, Zadeh Jenia Kouchek, Pfeiffer Norbert, Xia Ning, Li Huige, Wess Juergen, Gericke Adrian, The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice, Scientific Reports, 9, 1, 2019. Crossref

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  241. Marlo Joy E., Niswender Colleen M., Days Emily L., Bridges Thomas M., Xiang Yun, Rodriguez Alice L., Shirey Jana K., Brady Ashley E., Nalywajko Tasha, Luo Qingwei, Austin Cheryl A., Williams Michael Baxter, Kim Kwangho, Williams Richard, Orton Darren, Brown H. Alex, Lindsley Craig W., Weaver C. David, Conn P. Jeffrey, Discovery and Characterization of Novel Allosteric Potentiators of M1Muscarinic Receptors Reveals Multiple Modes of Activity, Molecular Pharmacology, 75, 3, 2009. Crossref

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  249. NARIMATSU Naho, SAITO Motoaki, KAZUYAMA Emi, HISADOME Yoshie, KINOSHITA Yukako, SATOH Itaru, OKADA Shin-ichi, SUZUKI Hiroto, YAMADA Masashi, SATOH Keisuke, N-hexacosanol prevents diabetes-induced rat ileal dysfunction without qualitative alteration of the muscarinic receptor system, Biomedical Research, 28, 5, 2007. Crossref

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  254. Silva Marcelo Florencio Passos, Alves Patricia Lucio, Alponti Rafaela Fadoni, Silveira Paulo Flavio, Abdalla Fernando Maurício Francis, Effects of obesity induced by high-calorie diet and its treatment with exenatide on muscarinic acetylcholine receptors in rat hippocampus, Biochemical Pharmacology, 169, 2019. Crossref

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  325. Song Pingfang, Sekhon Harmanjatinder S., Lu Allison, Arredondo Juan, Sauer David, Gravett Courtney, Mark Gregory P., Grando Sergei A., Spindel Eliot R., M3 Muscarinic Receptor Antagonists Inhibit Small Cell Lung Carcinoma Growth and Mitogen-Activated Protein Kinase Phosphorylation Induced by Acetylcholine Secretion, Cancer Research, 67, 8, 2007. Crossref

  326. McMillin Sara M., Heusel Moritz, Liu Tong, Costanzi Stefano, Wess Jürgen, Structural Basis of M3 Muscarinic Receptor Dimer/Oligomer Formation, Journal of Biological Chemistry, 286, 32, 2011. Crossref

  327. Lamping Kathryn G., Wess Jürgen, Cui Yinghong, Nuno Daniel W., Faraci Frank M., Muscarinic (M) Receptors in Coronary Circulation, Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 7, 2004. Crossref

  328. Kostenis Evi, Gomeza Jesus, Lerche Christian, Wess Jürgen, Genetic Analysis of Receptor-Gαq Coupling Selectivity, Journal of Biological Chemistry, 272, 38, 1997. Crossref

  329. Han Sung-Jun, Hamdan Fadi F., Kim Soo-Kyung, Jacobson Kenneth A., Brichta Lars, Bloodworth Lanh M., Li Jian H., Wess Jürgen, Pronounced Conformational Changes following Agonist Activation of the M3 Muscarinic Acetylcholine Receptor, Journal of Biological Chemistry, 280, 26, 2005. Crossref

  330. Pavlov Valentin A., Ochani Mahendar, Gallowitsch-Puerta Margot, Ochani Kanta, Huston Jared M., Czura Christopher J., Al-Abed Yousef, Tracey Kevin J., Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia, Proceedings of the National Academy of Sciences, 103, 13, 2006. Crossref

  331. Duttaroy Alokesh, Zimliki Charles L., Gautam Dinesh, Cui Yinghong, Mears David, Wess Jürgen, Muscarinic Stimulation of Pancreatic Insulin and Glucagon Release Is Abolished in M3 Muscarinic Acetylcholine Receptor–Deficient Mice, Diabetes, 53, 7, 2004. Crossref

  332. Li Bo, Nowak Nicola M., Kim Soo-Kyung, Jacobson Kenneth A., Bagheri Ali, Schmidt Clarice, Wess Jürgen, Random Mutagenesis of the M3 Muscarinic Acetylcholine Receptor Expressed in Yeast, Journal of Biological Chemistry, 280, 7, 2005. Crossref

  333. Liu Hongtao, Hofmann Josefa, Fish Inbar, Schaake Benjamin, Eitel Katrin, Bartuschat Amelie, Kaindl Jonas, Rampp Hannelore, Banerjee Ashutosh, Hübner Harald, Clark Mary J., Vincent Sandra G., Fisher John T., Heinrich Markus R., Hirata Kunio, Liu Xiangyu, Sunahara Roger K., Shoichet Brian K., Kobilka Brian K., Gmeiner Peter, Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists, Proceedings of the National Academy of Sciences, 115, 47, 2018. Crossref

  334. Takizuka Atsushi, Minami Kouichiro, Uezono Yasuhito, Horishita Takafumi, Yokoyama Toru, Shiraishi Munehiro, Sakurai Takeshi, Shigematsu Akio, Ueta Yoichi, Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenopus oocytes and muscarine-induced intracellular Ca2+ elevation in cultured rat dorsal root ganglia cells, Naunyn-Schmiedeberg's Archives of Pharmacology, 375, 5, 2007. Crossref

  335. Basile Anthony S., Fedorova Irina, Zapata Agustin, Liu Xiaoguang, Shippenberg Toni, Duttaroy Alokesh, Yamada Masahisa, Wess Jürgen, Deletion of the M 5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia , Proceedings of the National Academy of Sciences, 99, 17, 2002. Crossref

  336. Gerber David J., Sotnikova Tatyana D., Gainetdinov Raul R., Huang Shu Ying, Caron Marc G., Tonegawa Susumu, Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice, Proceedings of the National Academy of Sciences, 98, 26, 2001. Crossref

  337. Hansen Gesine, Jin S.-L. Catherine, Umetsu Dale T., Conti Marco, Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D, Proceedings of the National Academy of Sciences, 97, 12, 2000. Crossref

  338. Gomeza Jesus, Shannon Harlan, Kostenis Evi, Felder Christian, Zhang Lu, Brodkin Jesse, Grinberg Alexander, Sheng Hui, Wess Jürgen, Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice, Proceedings of the National Academy of Sciences, 96, 4, 1999. Crossref

  339. Chen Shao-Rui, Chen Hong, Yuan Wei-Xiu, Wess Jürgen, Pan Hui-Lin, Dynamic Control of Glutamatergic Synaptic Input in the Spinal Cord by Muscarinic Receptor Subtypes Defined Using Knockout Mice, Journal of Biological Chemistry, 285, 52, 2010. Crossref

  340. Scarselli Marco, Li Bo, Kim Soo-Kyung, Wess Jürgen, Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation, Journal of Biological Chemistry, 282, 10, 2007. Crossref

  341. Yamada Masahisa, Lamping Kathryn G., Duttaroy Alokesh, Zhang Weilie, Cui Yinghong, Bymaster Frank P., McKinzie David L., Felder Christian C., Deng Chu-Xia, Faraci Frank M., Wess Jürgen, Cholinergic dilation of cerebral blood vessels is abolished in M 5 muscarinic acetylcholine receptor knockout mice , Proceedings of the National Academy of Sciences, 98, 24, 2001. Crossref

  342. Das Krishnendu, Gabrielli Luca, Prins Leonard J., Chemically Fueled Self‐Assembly in Biology and Chemistry, Angewandte Chemie International Edition, 60, 37, 2021. Crossref

  343. Schmidt Clarice, Li Bo, Bloodworth Lanh, Erlenbach Isolde, Zeng Fu-Yue, Wess Jürgen, Random Mutagenesis of the M3 Muscarinic Acetylcholine Receptor Expressed in Yeast, Journal of Biological Chemistry, 278, 32, 2003. Crossref

  344. Das Krishnendu, Gabrielli Luca, Prins Leonard J., Chemically Fueled Self‐Assembly in Biology and Chemistry, Angewandte Chemie, 133, 37, 2021. Crossref

  345. Wess Jürgen, Muscarinic Receptors, in Encyclopedia of Molecular Pharmacology, 2021. Crossref

  346. Thompson Karen J., Tobin Andrew B., Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer's disease?, Cellular Signalling, 70, 2020. Crossref

  347. McClatchy Daniel B., Knudsen Charlotte R., Clark Brian F., Kahn Richard A., Hall Randy A., Levey Allan I., Novel Interaction between the M4 Muscarinic Acetylcholine Receptor and Elongation Factor 1A2, Journal of Biological Chemistry, 277, 32, 2002. Crossref

  348. Tzavara E T, Bymaster F P, Felder C C, Wade M, Gomeza J, Wess J, McKinzie D L, Nomikos G G, Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice, Molecular Psychiatry, 8, 7, 2003. Crossref

  349. Poulsen Frantz Rom, Jahnsen Henrik, Blaabjerg Morten, Zimmer Jens, Pilocarpine-induced seizure-like activity with increased BNDF and neuropeptide Y expression in organotypic hippocampal slice cultures, Brain Research, 950, 1-2, 2002. Crossref

  350. Ruiz de Azua Inigo, Scarselli Marco, Rosemond Erica, Gautam Dinesh, Jou William, Gavrilova Oksana, Ebert Philip J., Levitt Pat, Wess Jürgen, RGS4 is a negative regulator of insulin release from pancreatic β-cells in vitro and in vivo, Proceedings of the National Academy of Sciences, 107, 17, 2010. Crossref

  351. Gomeza Jesus, Zhang Lu, Kostenis Evi, Felder Christian, Bymaster Frank, Brodkin Jesse, Shannon Harlan, Xia Bing, Deng Chu-xia, Wess Jürgen, Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M 4 muscarinic acetylcholine receptor knockout mice , Proceedings of the National Academy of Sciences, 96, 18, 1999. Crossref

  352. Li Jian Hua, Han Sung-Jun, Hamdan Fadi F., Kim Soo-Kyung, Jacobson Kenneth A., Bloodworth Lanh M., Zhang Xiaohong, Wess Jürgen, Distinct Structural Changes in a G Protein-coupled Receptor Caused by Different Classes of Agonist Ligands, Journal of Biological Chemistry, 282, 36, 2007. Crossref

  353. Lin Kedan, Wang Danxin, Sadée Wolfgang, Serum Response Factor Activation by Muscarinic Receptors via RhoA, Journal of Biological Chemistry, 277, 43, 2002. Crossref

  354. Guerra Marcy L., Wauson Eric M., McGlynn Kathleen, Cobb Melanie H., Muscarinic Control of MIN6 Pancreatic β Cells Is Enhanced by Impaired Amino Acid Signaling, Journal of Biological Chemistry, 289, 20, 2014. Crossref

  355. Qian J, Galitovskiy V, Chernyavsky A I, Marchenko S, Grando S A, Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of naïve CD4 T cells toward the Th1, Th2 and Th17 lineages, Genes & Immunity, 12, 3, 2011. Crossref

  356. Chen Shao-Rui, Chen Hong, Yuan Wei-Xiu, Wess Jürgen, Pan Hui-Lin, Differential Regulation of Primary Afferent Input to Spinal Cord by Muscarinic Receptor Subtypes Delineated Using Knockout Mice, Journal of Biological Chemistry, 289, 20, 2014. Crossref

  357. Okoshi Katashi, Nakayama Masaharu, Yan Xinhua, Okoshi Marina P., Schuldt Adam J.T., Marchionni Mark A., Lorell Beverly H., Neuregulins Regulate Cardiac Parasympathetic Activity, Circulation, 110, 6, 2004. Crossref

  358. Nadler Laurie S., Kumar Geetha, Nathanson Neil M., Identification of a Basolateral Sorting Signal for the M3 Muscarinic Acetylcholine Receptor in Madin-Darby Canine Kidney Cells, Journal of Biological Chemistry, 276, 13, 2001. Crossref

  359. Billet Arnaud, Luo Yishan, Balghi Haouaria, Hanrahan John W., Role of Tyrosine Phosphorylation in the Muscarinic Activation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), Journal of Biological Chemistry, 288, 30, 2013. Crossref

  360. Erlenbach Isolde, Wess Jürgen, Molecular Basis of V2 Vasopressin Receptor/GsCoupling Selectivity, Journal of Biological Chemistry, 273, 41, 1998. Crossref

  361. Jiménez Esperanza, Fornés Amparo, Felipe Raquel, Núñez Enrique, Aragón Carmen, López-Corcuera Beatriz, Calcium-Dependent Regulation of the Neuronal Glycine Transporter GlyT2 by M2 Muscarinic Acetylcholine Receptors, Neurochemical Research, 47, 1, 2022. Crossref

  362. Nathanson Neil M., A multiplicity of muscarinic mechanisms: Enough signaling pathways to take your breath away, Proceedings of the National Academy of Sciences, 97, 12, 2000. Crossref

  363. Honda Kenji, Harada Akitsugu, Takano Yukio, Kamiya Hiro-o, Involvement of M3 muscarinic receptors of the spinal cord in formalin-induced nociception in mice, Brain Research, 859, 1, 2000. Crossref

  364. Wess Jürgen, Eglen Richard M., Gautam Dinesh, Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development, Nature Reviews Drug Discovery, 6, 9, 2007. Crossref

  365. Hu Jianxin, Hu Kelly, Liu Tong, Stern Matthew K., Mistry Rajendra, Challiss R.A.John, Costanzi Stefano, Wess Jürgen, Novel Structural and Functional Insights into M3 Muscarinic Receptor Dimer/Oligomer Formation, Journal of Biological Chemistry, 288, 48, 2013. Crossref

  366. Han Sung-Jun, Hamdan Fadi F., Kim Soo-Kyung, Jacobson Kenneth A., Bloodworth Lanh M., Li Bo, Wess Jürgen, Identification of an Agonist-induced Conformational Change Occurring Adjacent to the Ligand-binding Pocket of the M3 Muscarinic Acetylcholine Receptor, Journal of Biological Chemistry, 280, 41, 2005. Crossref

  367. Yang Jun-Min, Yang Xiao-Yu, Wan Jian-Hua, Multiple roles for cholinergic signaling in pancreatic diseases, World Journal of Gastroenterology, 28, 25, 2022. Crossref

  368. Calaf Gloria M., Role of organophosphorous pesticides and acetylcholine in breast carcinogenesis, Seminars in Cancer Biology, 76, 2021. Crossref

  369. Pfeiffer Julia B. R., Mevissen Meike, Steiner Adrian, Portier Christopher J., Meylan Mireille, In vitro effects of bethanechol on specimens of intestinal smooth muscle obtained from the duodenum and jejunum of healthy dairy cows, American Journal of Veterinary Research, 68, 3, 2007. Crossref

  370. Bai Yueqi, Wang Luozheng, Organophosphate-induced inhibition of acetylcholinesterase, oxidative stress and neuroinflammation, Highlights in Science, Engineering and Technology, 8, 2022. Crossref

  371. Golime RamaRao, Singh Naveen, Molecular interactions of chemical warfare agents with biological systems, in Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects, 2023. Crossref

  372. Naznin Farhana, Waise T. M. Zaved, Fernyhough Paul, Antagonism of the Muscarinic Acetylcholine Type 1 Receptor Enhances Mitochondrial Membrane Potential and Expression of Respiratory Chain Components via AMPK in Human Neuroblastoma SH-SY5Y Cells and Primary Neurons, Molecular Neurobiology, 59, 11, 2022. Crossref

  373. Sanders Kenton M., Baker Salah A., Drumm Bernard T., Kurahashi Masaaki, Ca2+ Signaling Is the Basis for Pacemaker Activity and Neurotransduction in Interstitial Cells of the GI Tract, in The Enteric Nervous System II, 1383, 2022. Crossref

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