RT Journal Article
ID 00d983fb2791ab09
A1 Rehman, Kanwal 
A1 Akash, Muhammad Sajid Hamid
A1 Liaqat, Aamira 
A1 Kamal, Shagufta 
A1 Qadir, Muhammad Imran
A1 Rasul, Akhtar 
T1 Role of Interleukin-6 in Development of Insulin Resistance and Type 2 Diabetes Mellitus
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2017
FD 2017-09-29
VO 27
IS 3
SP 229
OP 236
K1 Interleukin-6
K1 insulin resistance
K1 diabetes mellitus
K1 pro-inflammatory cytokines
AB Interleukin-6 (IL-6) is a proinflammatory cytokine that decisively induces the development of insulin
resistance and pathogenesis of type 2 diabetes mellitus (T2DM) through the generation of inflammation by controlling
differentiation, migration, proliferation, and cell apoptosis. The presence of IL-6 in tissues is a normal consequence, but its irregular production and long-term exposure leads to the development of inflammation, which induces insulin resistance and overt T2DM. There is a mechanistic relationship between the stimulation of IL-6 and insulin resistance. IL-6 causes insulin resistance by impairing the phosphorylation of insulin receptor and insulin receptor substrate-1 by inducing the expression of SOCS-3, a potential inhibitor of insulin signaling. In this article, we have briefly described how IL-6 induces the insulin resistance and pathogenesis of T2DM. The prevention of inflammatory disorders by blocking IL-6 and IL-6 signaling may be an effective strategy for the treatment of insulin resistance and T2DM.

PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,3e1db9ff199ae23c,00d983fb2791ab09.html