RT Journal Article
ID 08d0d2d677dedb52
A1 Bhave, Sanjay L.
A1 Teknos, Theodoras N. 
A1 Pan, Quintin
T1 Molecular Parameters of Head and Neck Cancer Metastasis
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2011
FD 2011-11-04
VO 21
IS 2
SP 143
OP 153
K1 HNSCC
K1 squamous cell carcinoma
K1 migration
K1 invasion
AB Metastasis remains a major cause of mortality in patients with head and neck squamous cell carcinoma (HNSCC). HNSCC patients with metastatic disease have extremely poor prognoses, with an average survival rate of less than a year. Metastasis is an intricate sequential process that requires a discrete population of tumor cells to possess the capacity to intravasate from the primary tumor into systemic circulation, survive in circulation, extravasate at a distant site, and proliferate in a foreign, hostile environment. Literature has accumulated to provide mechanistic insight into several signal transduction pathways, receptor tyro-sine kinases (RTKs), signal transducer and activator of transcription 3 (Stat3), Rho GTPases, protein kinase Cε (PKCsε), and nuclear factor-κB (NF-κB), that are involved in mediating a metastatic tumor cell phenotype in HN-SCC. Herein we highlight accrued information regarding the key molecular parameters of HNSCC metastasis.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,6f888cc8136a039b,08d0d2d677dedb52.html