RT Journal Article ID 0e8612c851939afa A1 Krimsky, Sheldon T1 Crossing the Germline Barrier: The Three Genome Baby JF Ethics in Biology, Engineering and Medicine: An International Journal JO EBEM YR 2015 FD 2016-08-18 VO 6 IS 3-4 SP 237 OP 261 K1 gene editing; germline; somatic cell genetic modification; Asilomar; CRISPR; ooplasmic transfer; mitochondrial disease; nuclear genome transplantation AB The moral boundary separating somatic cell genetic modification and germline genetic modification has been in effect for over 30 years. Recently, with the introduction of nuclear DNA transplantation and gene editing, and with the rising interest in preventing the transfer of certain deleterious genes to newborns, that moral boundary has been called into question. The paper discusses the origins of the somatic cell and germline moral distinction and explores new initiatives to undertake genetic modification of gametes or embryos. PB Begell House LK https://www.dl.begellhouse.com/journals/6ed509641f7324e6,06c96e9e620340c9,0e8612c851939afa.html