RT Journal Article ID 1cf9f3e375b905d0 A1 Bailey, Samantha L. A1 Carpentier, Pamela A. A1 McMahon, Eileen J. A1 Begolka, Wendy Smith A1 Miller, Stephen D. T1 Innate and Adaptive Immune Responses of the Central Nervous System JF Critical Reviews™ in Immunology JO CRI YR 2006 FD 2006-04-25 VO 26 IS 2 SP 149 OP 188 AB The central nervous system (CNS) is an immunologically specialized organ. The blood-brain barrier regulates the passage of molecules and cells into the CNS. Robust immune responses occur in the CNS even though there is normally an absence of MHC molecules, lack of normal lymphatic drainage, and reduced immune surveillance. This review discusses the immunological elements of the healthy CNS and the pattern of responses that evolve during innate and adaptive immunity in this organ. We also discuss the contribution of astrocytes, cerebrovascular endothelial cells, microglia, macrophages, and dendritic cells to the integrity and pathology of the CNS during CD4+ Т-cell autoimmune responses directed against neuroantigens. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,1f4a494c5e662938,1cf9f3e375b905d0.html