%0 Journal Article %A Xiao, Yongtao %A Chen , Yingwei %A Wen, Jie %A Yan, Weihui %A Zhou, Kejun %A Cai, Wei %D 2012 %I Begell House %K thymosin β4, inflammation, cell migration, inflammation, actin sequestering, cancer therapy %N 2 %P 109-116 %R 10.1615/CritRevEukarGeneExpr.v22.i2.30 %T Thymosin β4: A Potential Molecular Target for Tumor Therapy %U https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,7f7fb529655925d5,21f5bf211e30b8b7.html %V 22 %X Thymosin β4 (Tβ4), a 5 kDa protein, has been demonstrated to play an important role in a variety of biological activities, such as actin sequestering, cellular motility, migration, inflammation, and damage repair. Recently, several novel findings provided compelling evidence that Tβ4 played a key role in facilitating tumor metastasis and angiogenesis. It has been found that Tβ4 expressed increasingly in a number of metastatic tumors, which was associated with an increased expression of a known angiogenic factor, vascular endothelial growth factor. Thus, Tβ4 provided a potential target of opportunity for cancer management, especially for cancer metastasis therapy. %8 2012-08-02