RT Journal Article ID 292cb56e5af84ac7 A1 Ghosh-Choudhury, Nandini A1 Harris, Marie A. A1 Feng, Jian Q. A1 Mundy, Gregory R. A1 Harris, Stephen E. T1 Expression of the BMP 2 Gene during Bone Cell Differentiation JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 1994 FD 1994-09-30 VO 4 IS 2-3 SP 345 OP 355 K1 bone morphogenetic proteins K1 BMP 2 promoter K1 TGFβ K1 transgenic bone cell lines. AB Bone morphogenetic protein 2 (BMP 2) and transforming growth factor β (TGFβ) are actively involved in bone formation and remodeling. TGFβ, a powerful stimulant in the early stage of bone cell growth and matrix formation, inhibits differentiation and in vitro mineralized nodule formation in primary fetal rat calvarial osteoblast system. TGFβ also negatively regulates BMP 2 expression at the transcriptional level. BMP 2 gene expression is controlled by a battery of transcriptional factors, some known and some yet to be identified. Immortalized osteoblast cell lines generated from a transgenic mouse carrying BMP 2 promoter-driven SV40 large T antigen transgene are described as powerful tools for studying regulation of BMP 2 gene expression and bone cell differentiation at the molecular level. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,5c871a5075b926d8,292cb56e5af84ac7.html