RT Journal Article ID 2e49b07d34ee9023 A1 Mojadadi, Shafi A1 Ebtekar, Massoumeh A1 Hassan, Zuhair Mohammad T1 Immunomodulatory Effects of Ganoderma lucidum (W. Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) on CD4+/CD8+ Tumor Infiltrating Lymphocytes in Breast-Cancer-Bearing Mice JF International Journal of Medicinal Mushrooms JO IJM YR 2006 FD 2007-01-05 VO 8 IS 4 SP 315 OP 320 AB Ganoderma lucidum (Basidiomycetes) has been recognized as an immunomodulatory natural product. This study was performed in order to investigate the effects of G. lucidum polysaccharide (GL-PS) extract on tumor volume and T(CD4+/CD8+) ratio of tumor infiltrating lymphocytes (TILs) in breast cancer bearing mice. Initially, we performed the DTH (delayed type hypersensitivity) test for obtaining the most effective dose of GL-PS extract on induction of cell-mediated immune response. Then, we evaluated the effect of this dose on tumor volume and CD4+/CD8+ T subpopulations that infiltrated into cancerous breast tissue. Results indicated that GL-PS 100 mg/kg/day could effectively increase DTH response against sRBC in BALB/c mice. Furthermore, intraperitoneal injection of this extract in breast cancer bearing mice could increase T-cell infiltration into the tumor. Also, there was a significant increase in the CD4+/CD8+ ratio in tumor infiltrating lymphocytes as well as a decrease in tumor volume. We concluded that GL-PS can exhibit a potent immunomodulatory effect and may be used for potentiation of the immune system against diseases such as cancer and other conditions in which the immune response has been compromised. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,7c3e0ba845ba8869,2e49b07d34ee9023.html