RT Journal Article
ID 2e49b07d34ee9023
A1 Mojadadi, Shafi
A1 Ebtekar, Massoumeh
A1 Hassan, Zuhair Mohammad
T1 Immunomodulatory Effects of Ganoderma lucidum (W. Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) on CD4+/CD8+ Tumor Infiltrating Lymphocytes in Breast-Cancer-Bearing Mice
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2006
FD 2007-01-05
VO 8
IS 4
SP 315
OP 320
AB Ganoderma lucidum (Basidiomycetes) has been recognized as an immunomodulatory natural product. This study was performed in order to investigate the effects of G. lucidum polysaccharide (GL-PS) extract on tumor volume and T(CD4+/CD8+) ratio of tumor infiltrating lymphocytes (TILs) in breast cancer bearing mice. Initially, we performed the DTH (delayed type hypersensitivity) test for obtaining the most effective dose of GL-PS extract on induction of cell-mediated immune response. Then, we evaluated the effect of this dose on tumor volume and CD4+/CD8+ T subpopulations that infiltrated into cancerous breast tissue. Results indicated that GL-PS 100 mg/kg/day could effectively increase DTH response against sRBC in BALB/c mice. Furthermore, intraperitoneal injection of this extract in breast cancer bearing mice could increase T-cell infiltration into the tumor. Also, there was a significant increase in the CD4+/CD8+ ratio in tumor infiltrating lymphocytes as well as a decrease in tumor volume. We concluded that GL-PS can exhibit a potent immunomodulatory effect and may be used for potentiation of the immune system against diseases such as cancer and other conditions in which the immune response has been compromised.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,7c3e0ba845ba8869,2e49b07d34ee9023.html