RT Journal Article ID 4008c65255bf2a2a A1 Rubel, Rosalia A1 Santa, Herta Stutz Dalla A1 dos Santos, Leandro Freire A1 Fernandes, Luiz Claudio A1 Figueiredo, Bonald Cavalcante A1 Soccol, Carlos Ricardo T1 Immunomodulatory and Antitumoral Properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) Medicinal Mushrooms JF International Journal of Medicinal Mushrooms JO IJM YR 2018 FD 2018-05-16 VO 20 IS 4 SP 393 OP 403 K1 Agaricus brasiliensis K1 antitumor K1 Ganoderma lucidum K1 immunomodulator K1 medicinal mushrooms K1 solid-state culture AB Medicinal mushrooms are used in popular medicine largely as health promoters, mainly because of their antitumor and immunomodulatory activities. Ganoderma lucidum (lingzhi or reishi) and Agaricus brasiliensis are mushrooms that have long been used for medicinal purposes. This study evaluated their immunomodulatory and antitumor effects on mice fed a diet supplemented with G. lucidum and A. brasiliensis mycelia obtained from solid-state fermentation. For 14 weeks the mice were fed chow containing 50% A. brasiliensis and G. lucidum mycelia, using ground wheat as an excipient. The consumption of the supplemented diet inhibited Sarcoma 180 tumor growth and caused important changes in the immune system. The pattern of immune response shifted, increasing CD4+ and CD8+ and decreasing CD19+ cell populations. The restoration of a proper balance between cellular and humoral immunity is an essential process for restraining tumor growth. These results suggest that polysaccharides, such as β-glucans and other mushroom metabolites, possibly promote the T-cell dominance that is imperative to restrain tumor growth. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,31a39db86881b79c,4008c65255bf2a2a.html