RT Journal Article ID 42ed51fd0670aea6 A1 Abdulla, Mahmood Ameen A1 Fard, Atieh Abdollahi A1 Sabaratnam, Vikineswary A1 Wong, Kah-Hui A1 Kuppusamy, Umah Rani A1 Abdullah, Noorlidah A1 Ismail, Salmah T1 Potential Activity of Aqueous Extract of Culinary-Medicinal Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in Accelerating Wound Healing in Rats JF International Journal of Medicinal Mushrooms JO IJM YR 2011 FD 2011-03-22 VO 13 IS 1 SP 33 OP 39 K1 medicinal mushrooms K1 Hericium erinaceus K1 wound healing activity K1 Intrasite gel K1 histology K1 macrophages K1 collagen AB This study was conducted to evaluate the effects of topical application of aqueous extract of Hericium erinaceus fruiting bodies (HEFB) on the rate of wound healing enclosure and histology of the healed wound. Five groups of male Sprague-Dawley rats were experimentally wounded in the posterior neck area. A uniform wound area of 2.00 cm in diameter, using a circular stamp, was excised from the nape of the dorsal neck of all rats with the aid of a round seal. The animal groups were topically treated, respectively, with 0.2 mL each of sterilized distilled water (sdH2O); Intrasite gel; and 20, 30, and 40 mg/mL HEFB. Macroscopically, those rats whose wounds were dressed with HEFB and those in the Intrasite gel-treated group healed earlier than those treated with sdH2O. Histological analysis of healed wounds dressed with HEFB showed less scar width at wound enclosure and the healed wound contained fewer macrophages and more collagen with angiogenesis, compared to wounds dressed with sdH2O. In conclusion, wounds dressed with HEFB significantly enhanced the acceleration of wound healing enclosure in rats. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,77c52f4810e4b47b,42ed51fd0670aea6.html