RT Journal Article
ID 42ed51fd0670aea6
A1 Abdulla, Mahmood Ameen
A1 Fard, Atieh Abdollahi
A1 Sabaratnam, Vikineswary
A1 Wong, Kah-Hui
A1 Kuppusamy, Umah Rani
A1 Abdullah, Noorlidah
A1 Ismail, Salmah
T1 Potential Activity of Aqueous Extract of Culinary-Medicinal Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in Accelerating Wound Healing in Rats
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2011
FD 2011-03-22
VO 13
IS 1
SP 33
OP 39
K1 medicinal mushrooms
K1 Hericium erinaceus
K1 wound healing activity
K1 Intrasite gel
K1 histology
K1 macrophages
K1 collagen
AB This study was conducted to evaluate the effects of topical application of aqueous extract of Hericium erinaceus fruiting bodies (HEFB) on the rate of wound healing enclosure and histology of the healed wound. Five groups of male Sprague-Dawley rats were experimentally wounded in the posterior neck area. A uniform wound area of 2.00 cm in diameter, using a circular stamp, was excised from the nape of the dorsal neck of all rats with the aid of a round seal. The animal groups were topically treated, respectively, with 0.2 mL each of sterilized distilled water (sdH2O); Intrasite gel; and 20, 30, and 40 mg/mL HEFB. Macroscopically, those rats whose wounds were dressed with HEFB and those in the Intrasite gel-treated group healed earlier than those treated with sdH2O. Histological analysis of healed wounds dressed with HEFB showed less scar width at wound enclosure and the healed wound contained fewer macrophages and more collagen with angiogenesis, compared to wounds dressed with sdH2O. In conclusion, wounds dressed with HEFB significantly enhanced the acceleration of wound healing enclosure in rats.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,77c52f4810e4b47b,42ed51fd0670aea6.html