RT Journal Article ID 46704e71491bd63f A1 Maschio, Bianca Hessel A1 Gentil, Bianca Carvalho A1 Caetano, Erika Leão Ajala A1 Rodrigues, Lucas Silva A1 Laurino, Leticia Favara A1 Spim, Sara Rosicler Vieira A1 Jozala, Angela Faustino A1 dos Santos, Carolina Alves A1 Grotto, Denise A1 Gerenutti, Marli T1 Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats JF International Journal of Medicinal Mushrooms JO IJM YR 2017 FD 2017-12-26 VO 19 IS 11 SP 991 OP 1000 K1 food safety K1 gestational diabetes mellitus K1 Lentinus edodes K1 medicinal mushrooms K1 reproductive toxicology AB This study evaluated the protective effect of Lentinus edodes in rats with streptozotocin-induced gestational diabetes mellitus (STZ-GDM) when administered orally. The rats received from the 1st to the 19th day of gestation daily doses of 100 or 200 mg/kg of lyophilized and reconstituted L. edodes; the animals in the saline control group and diabetic control group received a saline solution (DS). Gestational diabetes mellitus was induced by streptozotocin (80 mg/kg, administered intraperitoneally) on the fourth day of pregnancy; blood glucose > 180 mg/dL was considered to indicate STZ-GDM. L. edodes reduced catalase in plasma. We also observed reduced glucose in plasma, urea, triglycerides, and aspartate aminotransferase. There was a decrease in preimplantation loss when compared with the DS group. The doses of L. edodes used here had a protective effect on the preimplantation parameters in STZGDM. However, the mushroom was not able to reverse the deleterious effects caused by streptozotocin throughout the evolution of pregnancy. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3e829fa15c9a53be,46704e71491bd63f.html