RT Journal Article
ID 496aff6004759563
A1 Zhang, Hongyuan
A1 Zhao, Wei
A1 Malhotra, Anshoo
T1 Efficacy of Curcumin in Ameliorating Aluminum- Induced Neurotoxicity
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2018
FD 2018-04-19
VO 37
IS 2
SP 163
OP 172
K1 aluminum
K1 cerebellum
K1 cerebrum
K1 curcumin
K1 neurotoxicity
AB Background−The present study evaluated the efficacy of curcumin as a nutritional supplement in
preventing aluminum-induced neurotoxicity in rats.
Methods−The rats were segregated into four groups, which included normal controls and aluminum-treated, curcumin-
treated, and aluminum- and curcumin-treated animals.
Results−Eight weeks of aluminum treatment resulted in a significant increase in the levels of lipid peroxidation
(LPO) and reactive oxygen species (ROS) in both cerebellum and cerebrum as compared to normal animals. In contrast, the activities of glutathione-S-transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD), and reduced glutathione (GSH) levels were found to be significantly decreased following aluminum treatment. Furthermore, aluminum resulted in anxiety in rats as determined with the elevated plus maze test. In addition, an appreciable decrease was noticed in both muscular and locomotor activity of aluminum-treated animals, as determined by rotarod and actophotometer tests, respectively. However, in aluminum-treated animals that also received curcumin supplements, the already raised levels of LPO and ROS returned to near normal limits in the cerebrum. Moreover, curcumin treatment of the aluminum-treated animals also resulted in a significant improvement in the levels of GSH
and enzyme activities of GST in both the cerebrum and cerebellum. Also, improvement was observed in the behavior
of aluminum-treated animals upon curcumin supplementation.
Conclusion−The present study suggests that curcumin may act as a neuroprotectant against aluminum-induced
neurodegenerative and behavioral disorders, but further investigations are needed to understand the exact mechanism
of neuroprotection.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,000ba8935c78b811,496aff6004759563.html