RT Journal Article
ID 4aabac842587672a
A1 Deng, Wanyan
A1 Tang, XieMei
A1 Hou, Manmei
A1 Li , Chunmei
A1 Xie, Jianping
T1 New Insights into the Pathogenesis of Tuberculosis Revealed by Mycobacterium marinum: The Zebrafish Model from the Systems Biology Perspective
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2011
FD 2011-12-12
VO 21
IS 4
SP 337
OP 346
K1 Tuberculosis
K1 pathogenesis
K1 M. marinum-zebrafish model
K1 systems biology.
AB Tuberculosis remains a worldwide health concern, largely due to the emergence of multi-drug-resistant (MDR) and extensive-drug-resistant (XDR) Mycobacterium tuberculosis co-infection with HIV. The exact mechanism of Mycobacterium virulence, pathogenesis, and persistence is not fully understood. The hallmark of tuberculosis, granulomas are promoted by Mycobacterium virulence factors, and they have long been considered a structural advantage to the host. However, this traditional view has been challenged recently, largely due to the evidence originating from the M. marinum-zebrafish model. As a genetically tractable model, zebrafish provide unprecedented opportunities to address the pathogenesis of tuberculosis from a systems biology perspective. The latest data from this model are summarized in this review, special attention is given to the shared pathway and network between zebrafish and humans. This research serves to deepen our understanding of this complex process and to promote the discovery of better countermeasures against tuberculosis.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,5879f5f63658cafa,4aabac842587672a.html