RT Journal Article ID 4e4ec48551ce88c5 A1 Hines , Daniel J. A1 Kaplan, David L. T1 Poly(lactic-co-glycolic) Acid−Controlled-Release Systems: Experimental and Modeling Insights JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2013 FD 2013-04-24 VO 30 IS 3 SP 257 OP 276 K1 PLGA K1 PLA K1 PGA K1 controlled release K1 mathematical modeling AB Poly(lactic-co-glycolic acid) (PLGA) has been the most successful polymeric biomaterial used in controlled drug delivery systems. There are several different chemical and physical properties of PLGA that impact the release behavior of drugs from PLGA delivery devices. These properties must be considered and optimized in the formulation of drug release devices. Mathematical modeling is a useful tool for identifying, characterizing, and predicting mechanisms of controlled release. The advantages and limitations of poly(lactic-co-glycolic acid) for controlled release are reviewed, followed by a review of current approaches in controlled-release technology that utilize PLGA. Mathematical modeling applied toward controlled-release rates from PLGA-based devices also will be discussed to provide a complete picture of a state-of-the-art understanding of the control that can be achieved with this polymeric system, as well as the limitations. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,2c11cd7727222f89,4e4ec48551ce88c5.html