RT Journal Article ID 51da61332c02fe9c A1 Sharma, Dr. Chandra Kant A1 Sharma, Vinay T1 Nephroprotective Effect of Jaggery against Acute and Subchronic Toxicity of Acetaminophen in Wistar Rats JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2012 FD 2013-01-03 VO 31 IS 3 SP 265 OP 272 K1 acetaminophen K1 antioxidant status K1 histopathology K1 jaggery K1 nephroprotective apoptosis K1 reactive oxygen species AB The present investigation was planned to evaluate the nephroprotective activity of jaggery against acetaminophen (APAP)-induced renal damage in rats. The protective activity of jaggery at different doses (250, 500, and 750 mg/kg, orally) was evaluated against oxidative damage induced by APAP administration (2 g/kg, once orally in acute exposure; 20 mg/kg, orally for 21 days in subchronic exposure) in rats. APAP administration significantly increased the levels of serum urea, creatinine, and renal lipid peroxidation (LPO), whereas substantial decreases were observed in levels of glutathione (GSH), adenosine triphosphatase (ATPase), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), and glutathione peroxidase (GPx) enzymatic activities after APAP administration. Administration of jaggery significantly moved the studied parameters toward normal levels and also reversed the histopathologic alterations. Thus, jaggery can be used to reduce renal damage and may serve as an alternative medicine in the treatment of renal etiologies. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,58960d9054b58e91,51da61332c02fe9c.html