RT Journal Article
ID 52863a3b07a06b68
A1 Yanchii, Roman I. 
A1 Voznesenska, Tetyana Yu. 
A1 Shepel, Olena A. 
A1 Bryzgina, Tetyana M.
A1 Sukhina, Vera S.
A1 Lazarenko, L. M. 
A1 Olenivska, Z. M. 
A1 Spivak, Mykola Ya. 
A1 Serbenjuk, R. M. 
A1 Serdyuk, O. M. 
T1 Production of Immunoregulatory Cytokines at Autoimmune Damage of Mammalian Ovaries
JF International Journal of Physiology and Pathophysiology
JO IJPP
YR 2010
FD 2010-11-23
VO 1
IS 3
SP 227
OP 234
K1 interferon
K1 tumor necrosis factor-alpha
K1 immune damage of ovaries 
AB Several ovarian disorders in women are associated with autoimmune factors. In this study it was investigated a level of cytokines &minus; TNF-<i>&#945;</i> and IFNs in ovarian homogenate and blood serum at ovarian autoimmune damage of mammals. Experimental immune ovarian failure was induced in CBA mice by either immunization with allogenic ovarian extracts or administration of xenogenic anti-ovarian antibodies. Both models were accompanied with abnormalities in production immunoregulatory cytokines. These data confirm importance of definition of proinflammatory cytokine level for disclosing immune mechanisms which lay in a pathogenesis autoimmune ovarian diseases of female reproductive organs.
PB Begell House
LK http://dl.begellhouse.com/journals/6ec4ba27650016b1,02dd64ad3178680a,52863a3b07a06b68.html