%0 Journal Article %A Gomez, Javier %A Gonzalez, Ana %A Martinez-A. , Carlos %A Rebollo, Angelita %D 1998 %I Begell House %K IL-2, IL-2 receptor, apoptosis, proliferation, GTP-binding proteins, bcl-2. %N 3 %P 185-220 %R 10.1615/CritRevImmunol.v18.i3.20 %T IL-2-lnduced Cellular Events %U https://www.dl.begellhouse.com/journals/2ff21abf44b19838,0e44a52b1e24194e,59fda5a66721e5e7.html %V 18 %X In this review we discuss several molecules that are attractive candidates as transducing molecules involved in signaling processes. IL-2 receptor signaling is a complex process involving a large number of molecules: Ras, Rho, PI3 kinase, PKC, Akt, transcription factors NF-AT, and NF-kB and some target genes such as bcl-2, c-myc, c-jun and c-fos. Ras and Rho have been defined as dual molecules because Ras- and Rho-initiated signals can either promote or inhibit apoptosis.
Several studies have contributed to the delineation of a signaling pathway structured in three independent channels designated channels 1, 2, and 3. These three channels serve as major landmarks: Lck-c-fos/c-jun (channel 1), Syk-myc (channel 2), and a pathway leading to actin organization/bcl-2 expression (channel 3). The detailed hierarchical organization of these three channels is presented throughout the review and the model is depicted in the figure. %8 1998-06-30