%0 Journal Article
%A Gomez, Javier
%A Gonzalez, Ana
%A Martinez-A. , Carlos
%A Rebollo, Angelita
%D 1998
%I Begell House
%K IL-2, IL-2 receptor, apoptosis, proliferation, GTP-binding proteins, bcl-2.
%N 3
%P 185-220
%R 10.1615/CritRevImmunol.v18.i3.20
%T IL-2-lnduced Cellular Events
%U https://www.dl.begellhouse.com/journals/2ff21abf44b19838,0e44a52b1e24194e,59fda5a66721e5e7.html
%V 18
%X In this review we discuss several molecules that are attractive candidates as transducing molecules involved in signaling processes. IL-2 receptor signaling is a complex process involving a large number of molecules: Ras, Rho, PI3 kinase, PKC, Akt, transcription factors NF-AT, and NF-kB and some target genes such as bcl-2, c-myc, c-jun and c-fos. Ras and Rho have been defined as dual molecules because Ras- and Rho-initiated signals can either promote or inhibit apoptosis.
Several studies have contributed to the delineation of a signaling pathway structured in three independent channels designated channels 1, 2, and 3. These three channels serve as major landmarks: Lck-c-fos/c-jun (channel 1), Syk-myc (channel 2), and a pathway leading to actin organization/bcl-2 expression (channel 3). The detailed hierarchical organization of these three channels is presented throughout the review and the model is depicted in the figure.
%8 1998-06-30