RT Journal Article
ID 5c3efd7d6612e435
A1 Gupta, Anuradha
A1 Pandya, Sanketkumar M.
A1 Mohammad, Imran
A1 Agrawal, Atul Kumar
A1 Mohan, Mradul
A1 Misra, Amit
T1 Particulate Pulmonary Delivery Systems Containing Anti-Tuberculosis Agents
JF Critical Reviews™ in Therapeutic Drug Carrier Systems
JO CRT
YR 2013
FD 2013-05-03
VO 30
IS 4
SP 277
OP 291
K1 inhalable; respirable; microspheres; microparticles; nanoparticles; rifampin; Isoniazid; lungs; alveolar macrophages; Mycobacterium tuberculosis
AB There is renewed interest in delivering anti-tuberculosis (TB) drugs to the lungs by inhalation. Several groups have investigated particulate pulmonary drug delivery formulations containing anti-TB agents, prepared using a variety of design approaches and processes. This review summarizes trends that indicate feasibility and translation of research efforts aimed at developing inhaled therapies for TB. Whereas formulations intended for reconstitution as solutions prior to nebulization can be produced with relative ease, particle engineering for powder formulations is more specialized. Spray drying and emulsion methods used to prepare particulate pulmonary delivery systems of anti-TB agents are compared. Pharmaceutical characterization is outlined. Administration of repeated inhalations to laboratory animals, especially under Animal Biosafety Level-3 (ABSL-3) containment as required for TB research, is another major challenge. Techniques employed by different groups are reviewed in the context of suitability for drug delivery and amenability towards use in ABSL-3 settings. It is concluded that spray drying is suitable for production of inhalable particles, rigorous physicochemical characterization is necessary for developing inhaled therapies as drug products, and pulmonary delivery of formulations containing anti-TB drugs to animals infected with Mycobacterium tuberculosis can best be carried out using handheld devices.
PB Begell House
LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,38d647663ccd959a,5c3efd7d6612e435.html