RT Journal Article
ID 69a1adc30c7d75f1
A1 Sovrani, Vanessa
A1 da Rosa, Juliana
A1 Drewinski, Mariana de Paula
A1 Colodi, Franciely Grose
A1 Tominaga, Tânia Toyomi
A1 Santa, Herta Stutz Dalla
A1 Rebeca, Rosilene
T1 In Vitro and In Vivo Antitumoral Activity of Exobiopolymers from the Royal Sun Culinary-Medicinal Mushroom Agaricus brasiliensis (Agaricomycetes)
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2017
FD 2017-11-01
VO 19
IS 9
SP 767
OP 775
K1 Agaricus brasiliensis
K1 exobiopolymers
K1 exopolysaccharide
K1 HeLa
K1 HEp-2
K1 medicinal mushrooms
K1 Walker 256 tumor
AB We studied antitumor activity in vitro and in vivo and partial chemical characterization of exobiopolymers (EBPs) of Agaricus brasiliensis produced by submerged cultivation. The EBPs comprised 61.2% total sugar and 22.3% total protein, and the chromatographic profile mainly identified mannose (65.5%), galactose (17.5%), and glucose (13.1%). In vitro analysis revealed a dose with antitumor effectiveness, time-dependent treatment, and 46% inhibition of solid Walker 256 tumors in rats. Metabolic changes were significant in the spleens of the animals; this is possibly related to higher immune activity triggered by the presence of EBPs in the treated group. The increase of nitric oxide production by peritoneal macrophages from animals may be related to the tumor reduction observed, because nitric oxide acts as an important effector pathway in the defense of the organism.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,53402a884df3ae15,69a1adc30c7d75f1.html