%0 Journal Article
%A Croccia, Carolina
%A Lopes, Agnaldo Jose
%A Pinto, Luis Felipe Ribeiro
%A Sabaa-Srur, Armando Ubirajara Oliveira
%A Vaz, Luiz Carlos Aguiar
%A Trotte, Marcele Nogueira de Sousa
%A Tessarollo, Bernardo
%A Silva, Aristofanes Correa
%A de Matos, Haroldo Jose
%A Nunes, Rodolfo Acatauassu
%D 2013
%I Begell House
%K medicinal mushrooms, Agaricus brasiliensis, carcinogenesis tests, drug therapy, inflammation, neoplasms, lung
%N 4
%P 345-355
%R 10.1615/IntJMedMushr.v15.i4.20
%T Royal Sun Medicinal Mushroom Agaricus brasiliensis (Higher Basidiomycetes) and the Attenuation of Pulmonary Inflammation Induced by 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK)
%U https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3eefb46658ba8153,6dde2a623a2dfeed.html
%V 15
%X Agaricus brasiliensis currently is one of the most studied fungi because of its nutritional and therapeutic properties as an anti-inflammatory agent and an adjuvant in cancer chemotherapy. The effects of orally administered aqueous A. brasiliensis extract (14.3- and 42.9-mg doses) on parenchymal lung damage induced by carcinogenic 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were observed in Wistar rats. NNK treatment induced pulmonary inflammation, but not lung cancer, in the rats. The lungs of animals treated with NNK showed a higher level of inflammation than those of the control group according to histopathologic examinations (P < 0.01) and kurtosis analysis (P < 0.001) of a global histogram generated from thoracic computed tomography scans. There was no significant difference in the alveolar and bronchial exudates between animals treated with a 14.3-mg dose of A. brasiliensis extract and the control without NNK. However, a significant difference was found between animals treated with NNK, received a 42.9-mg dose of A. brasiliensis (P < 0.05), and the controls not treated with NNK. We did not observe a significant difference between the kurtoses of the A. brasiliensis (14.3 mg) and control groups. However, a 42.9-mg dose of A. brasiliensis resulted in lower kurtosis values than those observed in the control group (P < 0.001). In conclusion, a low dose of A. brasiliensis was more effective in attenuating pulmonary inflammation. Similar to the histopathological results, the computed tomography scans also showed a protective effect of A. brasiliensis at the lower dose, which prevented gross pulmonary consolidation.
%8 2013-06-13