%0 Journal Article %A Croccia, Carolina %A Lopes, Agnaldo Jose %A Pinto, Luis Felipe Ribeiro %A Sabaa-Srur, Armando Ubirajara Oliveira %A Vaz, Luiz Carlos Aguiar %A Trotte, Marcele Nogueira de Sousa %A Tessarollo, Bernardo %A Silva, Aristofanes Correa %A de Matos, Haroldo Jose %A Nunes, Rodolfo Acatauassu %D 2013 %I Begell House %K medicinal mushrooms, Agaricus brasiliensis, carcinogenesis tests, drug therapy, inflammation, neoplasms, lung %N 4 %P 345-355 %R 10.1615/IntJMedMushr.v15.i4.20 %T Royal Sun Medicinal Mushroom Agaricus brasiliensis (Higher Basidiomycetes) and the Attenuation of Pulmonary Inflammation Induced by 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) %U https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3eefb46658ba8153,6dde2a623a2dfeed.html %V 15 %X Agaricus brasiliensis currently is one of the most studied fungi because of its nutritional and therapeutic properties as an anti-inflammatory agent and an adjuvant in cancer chemotherapy. The effects of orally administered aqueous A. brasiliensis extract (14.3- and 42.9-mg doses) on parenchymal lung damage induced by carcinogenic 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were observed in Wistar rats. NNK treatment induced pulmonary inflammation, but not lung cancer, in the rats. The lungs of animals treated with NNK showed a higher level of inflammation than those of the control group according to histopathologic examinations (P < 0.01) and kurtosis analysis (P < 0.001) of a global histogram generated from thoracic computed tomography scans. There was no significant difference in the alveolar and bronchial exudates between animals treated with a 14.3-mg dose of A. brasiliensis extract and the control without NNK. However, a significant difference was found between animals treated with NNK, received a 42.9-mg dose of A. brasiliensis (P < 0.05), and the controls not treated with NNK. We did not observe a significant difference between the kurtoses of the A. brasiliensis (14.3 mg) and control groups. However, a 42.9-mg dose of A. brasiliensis resulted in lower kurtosis values than those observed in the control group (P < 0.001). In conclusion, a low dose of A. brasiliensis was more effective in attenuating pulmonary inflammation. Similar to the histopathological results, the computed tomography scans also showed a protective effect of A. brasiliensis at the lower dose, which prevented gross pulmonary consolidation. %8 2013-06-13