RT Journal Article
ID 6f25614f56ff4da6
A1 Jain, Sanyog
A1 Dani, Prateek
A1 Sharma, Rakesh Kumar
T1 Pharmacoscintigraphy: A Blazing Trail for the Evaluation of New Drugs and Delivery Systems
JF Critical Reviews™ in Therapeutic Drug Carrier Systems
JO CRT
YR 2009
FD 2009-12-11
VO 26
IS 4
SP 373
OP 426
K1 gamma scintigraphy
K1 diagnostic imaging
K1 noninvasive imaging
K1 site targeting
K1 pharmacoscintigraphy
K1 novel drug delivery systems
AB The drug development process is becoming increasingly sophisticated; as a result, the need for rapid and accurate means of predicting the in vivo behavior of drug products continues to grow. Preclinical in vivo evaluations involve the sacrifice of many animals and hence raise ethical issues. Therefore, noninvasive methods for assessing the in vivo behavior of drug products in animals have become an attractive alternative. Gamma scintigraphy is an established radiological-imaging technique that has been used in medical practice for the past several decades. Gamma scintigraphy is also used during clinical evaluations to map the formulation as it traverses the human body in real time. Combining this information with the pharmacokinetic data gives valuable information about the release and absorption mechanisms of drugs from their products. This technique also provides a handy tool for evaluating formulations at the preclinical and clinical stages of development for researchers who work in targeted drug delivery using novel drug carrier systems. The current review explores the use of pharmacoscintigraphy, a science that integrates gamma scintigraphy and conventional pharmacokinetics in the process of drug development.
PB Begell House
LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,7b9ff1f536d6a3b9,6f25614f56ff4da6.html