RT Journal Article ID 7488d9a00f71890e A1 Polak, Paul A1 Tuyl, John Van A1 Engel, Robin T1 Imaging Chronic Traumatic Encephalopathy: A Biomedical Engineering Perspective JF Critical Reviews™ in Biomedical Engineering JO CRB YR 2016 FD 2017-12-26 VO 44 IS 6 SP 473 OP 492 K1 traumatic brain injury K1 chronic concussion K1 magnetic resonance imaging K1 proton emission tomography AB A disease initially associated with boxers ninety years ago, chronic traumatic encephalopathy (CTE) is now recognized as a significant risk to boxers, American football players, ice hockey players, military personnel or anyone to whom recurrent head injuries are a distinct possibility. Diagnosis is currently confirmed at autopsy, although CTE's presumed sufferers have symptoms of depression, suicidal thoughts, mood and personality changes, and loss of memory. CTE sufferers also complain of losing cognitive ability, dysfunction in everyday activities, inability to keep regular employment, violent tendencies and marital strife. Dementia may develop over the long term. Unfortunately, there is no clear consensus in regards to pathology, with both number and severity of head injuries being linked to disease progression. Despite the slow advancement of this disease, there are no clinical methods to diagnose or monitor prognosis in presumed patients, limiting clinicians' efforts to symptom management. The lack of diagnostic tools fuels the need for biomedical engineers to develop techniques for in vivo detection of CTE. This review examines efforts made with various magnetic resonance and nuclear imaging techniques, with a view towards improving the sensitivity and specificity of diagnostic imaging for CTE. PB Begell House LK https://www.dl.begellhouse.com/journals/4b27cbfc562e21b8,66797c07209e4e1f,7488d9a00f71890e.html