RT Journal Article
ID 7dad334131e14b8d
A1 Efferth, Thomas
A1 Greten, Henry Johannes
T1 Anti-Inflammatory and Anti-Cancer Activity of Boswellic Acids from Frankincense (Boswellia serrata Roxb. et Colebr, B. carterii Birdw.)
JF Onco Therapeutics
JO OT
YR 2011
FD 2012-04-25
VO 2
IS 4
SP 303
OP 313
K1 apoptosis
K1 cancer
K1 inflammation
K1 frankincense
K1 natural products
K1 olibanum
K1 in vitro
K1 in vivo, clinical trial
AB The oleo-resinous gum of Boswellia trees has been used for religious rituals, but also for medical purposes in different civilizations for ages. The active principles of the gum resin are boswellic acids. The ethnopharmacology of frankincense indicate activity towards inflammatory diseases and cancer. There is compelling evidence from experimental investigations that boswellic acids reveal anti-inflammatory activity, and the results of clinical trials confirm that Boswellia extracts are also clinically effective. No serious side effects were recorded. Occasional side effects included fatigue, vomiting, diarrhea, unspecific skin rash, azoospermia, and neutropenia. Several investigations using Boswellia extracts or isolated boswellic acids demonstrated growth inhibition of tumors in mice and rats, and increased survival time of animals. The treatment effects were associated with inhibition of AKT, reduced NF-κB activation, and down-regulation of anti-apoptotic proteins. Clinical application in glioblastoma patients showed an improvement of clinical symptoms in terms of edema reduction, but no reduction of tumor size.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2c6306423483e001,0f258d164f94b823,7dad334131e14b8d.html