RT Journal Article ID 7ec65e37441bd1a7 A1 Akahane, Katsuyuki A1 Satoh, Kaneo A1 Ohta, Masato A1 Ozaki, Yukio T1 Hot Water Extracts of the Royal Sun Mushroom, Agaricus brasiliensis (Higher Basidiomycetes), Inhibit Platelet Activation via the P2Y1 Receptor JF International Journal of Medicinal Mushrooms JO IJM YR 2015 FD 2015-11-09 VO 17 IS 8 SP 763 OP 770 K1 medicinal mushrooms K1 Agaricus brasiliensis K1 P2Y1 receptor K1 intracellular calcium K1 shape change AB Hot water extracts of the medicinal mushroom Agaricus brasiliensis were investigated for their inhibition of platelet aggregation. The extracts significantly inhibited human platelet aggregation induced by adenosine 5'-diphosphate (ADP), but not by collagen or thrombin receptor−activating peptide. The extracts also had a significant inhibitory effect on shape change and intracellular calcium mobilization induced by ADP via inhibition of ADP binding to the P2Y1 receptor. In addition, oral administration of the extracts resulted in prolonged tail bleeding time in mice. The marked antiplatelet activity of the mushroom extracts involving the P2Y1 receptor suggests their potential therapeutic use against vascular disorders. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,5c93eb0962bab6ac,7ec65e37441bd1a7.html