Abo Bibliothek: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Curcumin Augments the Efficacy of Antitumor Drugs Used in Leukemia by Modulation of Heat Shock Proteins Via HDAC6

Volumen 33, Ausgabe 3, 2014, pp. 247-263
DOI: 10.1615/JEnvironPatholToxicolOncol.2014010913
Get accessGet access

ABSTRAKT

Heat shock proteins (HSPs) and Histone deacetylase 6 (HDAC6) are induced under oxidative stress which promotes oncogenesis. HSPs are regulated by Heat shock factor1 (HSF1). HDAC6, a class IIb deacetylase, plays an essential role in tumorigenesis and cell stress response. HSPs, HSF1 and HDAC6 are up-regulated in cancer. Present study explored the effect of curcumin, a phytochemical on HSPs (27, 70, 90), HSF1 and HDAC6 in two different leukemia cell lines (K-562 and HL-60). The association between HDAC6, HSPs and intrinsic oxidative stress was also investigated. Over-expression of HSPs (27, 70, 90), HSF1, and HDAC6 in leukemia cells were down-regulated by curcumin. Effect on HSPs 27and 70 was less than that in HSP 90. This resulted in cell cycle arrest at G2/M stage leading to apoptosis. Different cell cycle regulatory proteins (p53, p21, Cyclin B1, CDK1, Cdc25C) and some apoptosis related proteins (Bcl-2, Bax, Bid, Bad, Apaf1, AIF and Cyt c) were altered by curcumin. Increased ROS level in leukemia cells were quenched by curcumin. A probable association between high ROS level and over-expression of the tumor markers was established in this study. Thus, curcumin enhanced the efficacy of anti-tumor drugs imatinib-mesylate and cytarabine through inhibition of the markers.

SCHLÜSSELWÖRTER: HSPs, HSF1, HDAC6, curcumin, ROS, leukemia
REFERENZIERT VON
  1. Sarkar Ruma, Mukherjee Sutapa, Biswas Jaydip, Roy Madhumita, Phenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1α as a putative target, Free Radical Research, 50, 1, 2016. Crossref

  2. Sashi Papu John A. M., Ankem Murali K., Damodaran Chendil, Oxidative Stress: a Promising Target for Chemoprevention, Current Pharmacology Reports, 2, 2, 2016. Crossref

  3. Mei Chen, He Sha-sha, Yin Peng, Xu Lei, Shi Ya-ran, Yu Xiao-hong, Lyu An, Liu Feng-hua, Jiang Lin-shu, Magnolol pretreatment attenuates heat stress-induced IEC-6 cell injury, Journal of Zhejiang University-SCIENCE B, 17, 6, 2016. Crossref

  4. Weng Jing-Ru, Bai Li-Yuan, Lin Wei-Yu, Chiu Chang-Fang, Chen Yu-Chang, Chao Shi-Wei, Feng Chia-Hsien, A Flavone Constituent from Myoporum bontioides Induces M-Phase Cell Cycle Arrest of MCF-7 Breast Cancer Cells, Molecules, 22, 3, 2017. Crossref

  5. BAHARUDDIN PUTERI, SATAR NAZILAH, FAKIRUDDIN KAMAL SHAIK, ZAKARIA NORASHIKIN, LIM MOON NIAN, YUSOFF NARAZAH MOHD, ZAKARIA ZUBAIDAH, YAHAYA BADRUL HISHAM, Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines, Oncology Reports, 35, 1, 2016. Crossref

  6. Bordoloi Devivasha, Kunnumakkara Ajaikumar B., The Potential of Curcumin: A Multitargeting Agent in Cancer Cell Chemosensitization, in Role of Nutraceuticals in Chemoresistance to Cancer, 2018. Crossref

  7. Mahanty Arabinda, Mohanty Sasmita, Mohanty Bimal P., Dietary supplementation of curcumin augments heat stress tolerance through upregulation of nrf-2-mediated antioxidative enzymes and hsps in Puntius sophore, Fish Physiology and Biochemistry, 43, 4, 2017. Crossref

  8. Gezer Ceren, Stress Response of Dietary Phytochemicals in a Hormetic Manner for Health and Longevity, in Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics, 2018. Crossref

  9. Forouzanfar Fatemeh, Barreto George, Majeed Muhammed, Sahebkar Amirhossein, Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach, BioFactors, 45, 5, 2019. Crossref

  10. Venkateshbabu Nagendrababu , Anand Suresh, Abarajithan Mohan, Sheriff Sultan O., Jacob Pulikkotil S., Sonia Nath, Natural Therapeutic Options in Endodontics - A Review, The Open Dentistry Journal, 10, 1, 2016. Crossref

  11. Verza Flávia Alves, Das Umashankar, Fachin Ana Lúcia, Dimmock Jonathan R., Marins Mozart, Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy, Cancers, 12, 6, 2020. Crossref

  12. San Tin Tin, Khaenam Prasong, Prachayasittikul Virapong, Sripa Banchob, Kunkeaw Nawapol, Chan-on Waraporn, Curcumin enhances chemotherapeutic effects and suppresses ANGPTL4 in anoikis-resistant cholangiocarcinoma cells, Heliyon, 6, 1, 2020. Crossref

  13. Zoltán Oláh, László Pecze, Éva Kocsis, Béla Viskolcz, A “keto-enol” plaque buster mechanism to diminish Alzheimer’s β-Amyloid burden, Biochemical and Biophysical Research Communications, 532, 1, 2020. Crossref

  14. Dawood Mona, Elbadawi Mohamed, Böckers Madeleine, Bringmann Gerhard, Efferth Thomas, Molecular docking-based virtual drug screening revealing an oxofluorenyl benzamide and a bromonaphthalene sulfonamido hydroxybenzoic acid as HDAC6 inhibitors with cytotoxicity against leukemia cells, Biomedicine & Pharmacotherapy, 129, 2020. Crossref

  15. Lourenço de Freitas Natália, Deberaldini Maria Gabriela, Gomes Diana, Pavan Aline Renata, Sousa Ângela, Dos Santos Jean Leandro, Soares Christiane P., Histone Deacetylase Inhibitors as Therapeutic Interventions on Cervical Cancer Induced by Human Papillomavirus, Frontiers in Cell and Developmental Biology, 8, 2021. Crossref

  16. Copetti Priscila Marquezan, Bissacotti Bianca Fagan, da Silva Gündel Samanta, Bottari Nathieli Bianchin, Sagrillo Michele Rorato, Machado Alencar Kolinski, Ourique Aline Ferreira, Chitolina Schetinger Maria Rosa, Schafer da Silva Aleksandro, Pharmacokinetic profiles, cytotoxicity, and redox metabolism of free and nanoencapsulated curcumin, Journal of Drug Delivery Science and Technology, 72, 2022. Crossref

  17. Ruzic Dusan, Djoković Nemanja, Srdić-Rajić Tatjana, Echeverria Cesar, Nikolic Katarina, Santibanez Juan F., Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention, Pharmaceutics, 14, 1, 2022. Crossref

  18. Wang Hui, Ling Li, Ai Limei, Bai Liping, HDAC6 inhibition induces the failure of mouse early embryonic development, Journal of Cellular Physiology, 234, 6, 2019. Crossref

  19. Khatoon Elina, Banik Kishore, Harsha Choudhary, Sailo Bethsebie Lalduhsaki, Thakur Krishan Kumar, Khwairakpam Amrita Devi, Vikkurthi Rajesh, Devi Thengujam Babita, Gupta Subash C., Kunnumakkara Ajaikumar B., Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives, Seminars in Cancer Biology, 80, 2022. Crossref

  20. Lernoux Manon, Schnekenburger Michael, Dicato Mario, Diederich Marc, Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways, Pharmacological Research, 129, 2018. Crossref

  21. Zhdanovskaya Nadezda, Lazzari Sara, Caprioglio Diego, Firrincieli Mariarosaria, Maioli Chiara, Pace Eleonora, Imperio Daniela, Talora Claudio, Bellavia Diana, Checquolo Saula, Mori Mattia, Screpanti Isabella, Minassi Alberto, Palermo Rocco, Identification of a Novel Curcumin Derivative Influencing Notch Pathway and DNA Damage as a Potential Therapeutic Agent in T-ALL, Cancers, 14, 23, 2022. Crossref

1576 Artikelansichten 57 Artikel-Downloads Metriken
1576 ANSICHTEN 57 HERUNTERLADEN 21 Crossref ZITATE Google
Scholar
ZITATE

Artikel mit ähnlichem Inhalt:

A Review of Molecular Mechanisms in the Development of Hepatocellular Carcinoma by Aflatoxin and Hepatitis B and C Viruses Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 2
Suman Dhanda, Vandana Moudgil, Davender Redhu, Jasbir Singh
KLF4 in Ovarian Cancer Onco Therapeutics, Vol.7, 2016, issue 1-2
Lawrence M. Pfeffer, Baojin Wang, Ziyun Du, Junming Yue
Comprehensive Characterization of HATs and HDACs in Human Cancers Reveals Their Role in Immune Checkpoint Blockade Critical Reviews™ in Eukaryotic Gene Expression, Vol.34, 2024, issue 1
Rong Sun, Xuanhao Qu, Weibing Zhang, Yihui Fan, Jie Zhang, Zhuheng Zhong, Zike Chen, Lehan Liu
Induction of Apoptosis and Chemosensitization by the Histone Deacetylase Inhibitor Trichostatin in Hepatocellular Carcinoma Cells: Molecular Analysis and RKIP Levels Onco Therapeutics, Vol.2, 2011, issue 2
Luigi Inguglia, Manuela Labbozzetta, Paola Poma, Monica Notarbartolo, Natale D'Alessandro
Diallyl Disulfide Induces Caspase-Dependent Apoptosis via Mitochondria-Mediated Intrinsic Pathway in B16F-10 Melanoma Cells by Up-Regulating P53, Caspase-3 and Down-Regulating Pro-Inflammatory Cytokines and Nuclear Factor- κβ-Mediated Bcl-2 Activation Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 2
P. Pratheeshkumar, Girija Kuttan, P. Thejass
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain