Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Journal of Environmental Pathology, Toxicology and Oncology
Impact-faktor: 1.625 5-jähriger Impact-Faktor: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i2.90
pages 143-147

Improving the Management of Bladder Cancer with Fluorescence Cystoscopy

H. Barton Grossman
Department of Urology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1373, Houston, TX 77030, USA

ABSTRAKT

Endoscopic visualization (cystoscopy) and transurethral resection are effective, well-tolerated diagnostic and treatment techniques for bladder cancer. However, it is widely recognized that cystoscopy can miss biologically important lesions, such as carcinoma in situ. Attempts to improve the effectiveness of cystoscopy are not new, but initial methods were impractical and had limited efficacy. Fluorescence cystoscopy became feasible with the discovery that intravesical administration of aminolevulinic acid (ALA) made bladder cancers fluoresce when exposed to blue light. More recently, the creation of a hexyl ester of ALA (HAL) made this technique practical, because HAL significantly shortens the amount of time needed for drug exposure prior to cystoscopy. Not surprisingly, studies have shown that fluorescence cystoscopy can reveal carcinoma in situ that is visually occult under conventional (white-light) cystoscopy. An unexpected finding was that fluorescence cystoscopy also enhanced the detection of papillary tumors. Studies with ALA have shown that resection of bladder cancer with fluorescence results in improved disease-free survival compared to conventional resection under white light. This report summarizes some of the recent studies of fluorescence cystoscopy in bladder cancer.


Articles with similar content:

Photodynamic Applications in Superficial Bladder Cancer: Facts and Hopes!
Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 1-2
Patrice Jichlinski
Preface: Special Issue of Photodynamic Therapy and Photodetection with Porphyrin Precursors for the Journal of Environmental Pathology, Toxicology, and Oncology
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 2
Alcira Batlle, Qian Peng
Utility of the F98 Rat Glioma Model for Photodynamic Therapy
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 2
Henry Hirschberg, Steen J. Madsen, Khishigzaya Kharkhuu
Potentiation of the Photodynamic Action of Hypericin
Journal of Environmental Pathology, Toxicology and Oncology, Vol.27, 2008, issue 1
Paul Wan Sia Heng, Constance Lay Lay Saw, Malini Olivo
Emerging Trends in Non-Interferon-Based Genotype-Specific Antiviral Agents: Pharmaceutical Perspectives
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 4
Tahir Farooq, Muhammad Ibrahim, Tahsin Gulzar, Matloob Ahmed, Muhammad Sajid Hamid Akash, Arruje Hameed, Kanwal Rehman