Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Journal of Environmental Pathology, Toxicology and Oncology
Impact-faktor: 1.625 5-jähriger Impact-Faktor: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2016015633
pages 147-159

Dietary Nanosized Lactobacillus plantarum Enhances the Anticancer Effect of Kimchi on Azoxymethane and Dextran Sulfate Sodium−Induced Colon Cancer in C57BL/6J Mice

Hyun Ah Lee
Department of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02856, Republic of Korea
Hyunung Kim
Biogenics Korea Co., Seoul 06628, Republic of Korea
Kwang-Won Lee
Department of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02856, Republic of Korea
Kun-Young Park
Department of Food Science and Biotechnology, College of Life Sciences, Cha University, Bundang-gu, Seongnam-si, Gyeonggi-do, 13488, Republic of Korea

ABSTRAKT

This study was undertaken to evaluate enhancement of the chemopreventive properties of kimchi by dietary nanosized Lactobacillus (Lab.)plantarum (nLp) in an azoxymethane (AOM)/dextran sulfate sodium (DSS)−induced colitis-associated colorectal cancer C57BL/6J mouse model. nLp is a dead, shrunken, processed form of Lab. Plantarum isolated from kimchi that is 0.5−1.0 µm in size. The results obtained showed that animals fed kimchi with nLp (K-nLp) had longer colons and lower colon weights/length ratios and developed fewer tumors than mice fed kimchi alone (K). In addition, K-nLp administration reduced levels of proinflammatory cytokine serum levels and mediated the mRNA and protein expressions of inflammatory, apoptotic, and cell-cycle markers to suppress inflammation and induce tumor-cell apoptosis and cell-cycle arrest. Moreover, it elevated natural killer-cell cytotoxicity. The study suggests adding nLp to kimchi could improve the suppressive effect of kimchi on AOM/DSS-induced colorectal cancer. These findings indicate nLp has potential use as a functional chemopreventive ingredient in the food industry.


Articles with similar content:

Daidzein Ameliorates Dextran Sulfate Sodium-Induced Experimental Colitis in Mice by Regulating NF-κB Signaling
Journal of Environmental Pathology, Toxicology and Oncology, Vol.38, 2019, issue 1
Na Li, Xi Zhang, Jiangli Shen
Antimalarial and Hepatoprotective Effects of Crude Ethanolic Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.)P.Karst. (Higher Basidiomycetes), in Plasmodium berghei-Infected Mice
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 5
Olarewaju M. Oluba, E. Chukwu Onyeneke, Augustine O. Olusola, Bamidele S. Fagbohunka
Effect of the King Oyster Culinary-Medicinal Mushroom Pleurotus eryngii (Agaricomycetes) Basidiocarps Powder to Ameliorate Memory and Learning Deficit in Ability in Aβ-Induced Alzheimer's Disease C57BL/6J Mice Model
International Journal of Medicinal Mushrooms, Vol.22, 2020, issue 2
Po-Chang Huang, Jeng-Leun Mau, Shen-Shih Chiang, Chih-Hung Liang
Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 3
Hong-Yu Xu, Xin Xu, Zhenming Lu, Yan Geng, Mingming Qin, Zheng-Hong Xu, Jin-Song Shi
Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 9
Yoshiyuki Adachi, Daisuke Yamanaka, Toshitsugu Miyazaki, Hisatomi Ito, Yuina Ishimoto, Kentaro Igami, Naohito Ohno, Ken-ichi Ishibashi