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Journal of Environmental Pathology, Toxicology and Oncology
Impact-faktor: 1.15 5-jähriger Impact-Faktor: 1.4 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2017018602
pages 207-216

Relationship between Topoisomerase II Alpha Overexpression and Prognosis in Chinese Gastric Cancer Patients

Fangchao Zheng
Department of Medical Oncology, Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China; Department of Medical Oncology, Shouguang Hospital of Traditional Chinese Medicine, Weifang, 261000, China
Jiuda Zhao
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Feng Du
Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China
Junhui Zhao
Affiliated Hospital of Qinghai University, Qinghai University, Xining, China
Guoshuang Shen
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Fei Ma
Institute of Refrigeration and Cryogenics, MOE Key Laboratory for Power Machinery and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
Xinfu Ma
Department of Medical Oncology, Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China
Li Dong
Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China
Wei Ma
Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China
Cunfang Shen
Affiliated Hospital of Qinghai University, Qinghai University, Xining, China
Shuyan Wang
Affiliated Hospital of Qinghai University, Qinghai University, Xining, China
Jinhua Ma
Affiliated Hospital of Qinghai University, Qinghai University, Xining, China
Yang Luo
Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China
Ziyi Wang
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Binghe Xu
Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China

ABSTRAKT

The aim of this study was to investigate topoisomerase II alpha (TOP2α) overexpression and its association with clinicopathological features and prognosis in gastric cancer (GC) patients. All selected GC patients at Affiliated Hospital of Qinghai University and Cancer Hospital, Chinese Academy of Medical Sciences, between December 2009 and December 2011, had formalin-fixed and paraffin-embedded tumor tissues. The patients received a telephone follow-up or in-/outpatient review, and their clinicopathological features and prognoses were analyzed. Also, the relationship between TOP2α expression and postoperative chemotherapy in GC patients was estimated. The results of the study showed that TOP2α overexpression correlated with location of tumor, depth of invasion, and pTNM stage. Moreover, it was associated with lower 5-year overall survival (OS) in noncardia GC patients younger than 60 years, with multivariate analysis demonstrating that it was an independent prognostic factor for these patients. Univariate analysis and multivariate analysis showed that TOP2α overexpression was associated with worse 5-year OS in noncardia GC patients ≤ 60 years receiving postoperative chemotherapy. TOP2α overexpression exhibited associations with location of tumor, depth of invasion, pTNM stage, and postoperative chemotherapy, making it a potential target for early diagnosis of GC patients. In addition, TOP2α overexpression was shown to be a predictor of 5-year OS in both noncardia GC patients ≤ 60 years and noncardia GC patients ≤ 60 years and receiving postoperative chemotherapy.


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