Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Journal of Environmental Pathology, Toxicology and Oncology
Impact-faktor: 1.241 5-jähriger Impact-Faktor: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i3.10
pages 179-187

Hepatoprotection of Gentiana scabra Extract and Polyphenols in Liver of Carbon Tetrachloride-Intoxicated Mice

Huey-Jiun Ko
Department of Food Science, National Chiayi University, Chiayi, Taiwan
Jyun-Han Chen
Department of Food Science and Technology, Tajen University, Pingtung, Taiwan
Lean Teik Ng
Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan

ABSTRAKT

In traditional Chinese medicine, the rhizomes of Gentiana scabra are used to treat hepatitis, stomatitis, and inflammatory diseases. This study aimed to examine the protective effects of G. scabra aqueous extract (GS) and polyphenols in liver of CCl4-intoxicated mice. Antioxidant activities of GS were also evaluated. Results showed that GS exhibited anti-lipid peroxidation, 2,2-diphenyl-1-picrylhydrazyl, and superoxide radical scavenging activities with IC50 values of 45.84, 183.38, and 56.25 μ/mL, respectively. High-performance liquid chromatography analysis revealed that the major polyphenolic constituents of GS were kaempferol, ellagic acid, and quercetin. Daily oral administration of 500 mg/kg GS (GS500) and 1000 mg/kg GS (GS1000) significantly prevented the elevation of glutamic pyruvic transaminase and thiobarbituric acid reactive substances levels, while enhancing the levels of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and serum total antioxidant activity in mice with hepatoxicity. At 1000 mg/kg, GS was as effective as 100 mg/kg silymarin in reducing oxidative stress and preventing liver injury. Histopathological studies further confirmed the hepatoprotective activity of GS. Taken together, these results show that the antioxidant activities and polyphenolic compounds (kaempferol, ellagic acid, and quercetin) of GS may have contributed to its hepatoprotective activity in CCl4-intoxicated mice, and its mechanism of action could be mediated through the reduction of oxidative stress in liver tissue.


Articles with similar content:

Hypoglycemic and Hypolipidemic Effects of the Cracked-Cap Medicinal Mushroom Phellinus rimosus (Higher Basidiomycetes) in Streptozotocin-Induced Diabetic Rats
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 6
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan, Kuttikkadan A. Rony
The Influence of Gingerol Treatment on Aluminum Toxicity in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 1
Sadhana Shrivastava
Study of the Protective Effects of Katha (Heartwood Extract of Acacia catechu) in Liver Damage Induced by Iron Overload
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 3
Nikhil Baban Ghate, Dipankar Chaudhuri, Nripendranath Mandal, Rhitajit Sarkar, Bibhabasu Hazra
Effects of Total Triterpenoids Extract from Ganoderma Iucidum (Curt.: Fr.) P. Karst. (Reishi Mushroom) on Experimental Liver Injury Models Induced by Carbon Tetrachloride or D-Galactosamine in Mice
International Journal of Medicinal Mushrooms, Vol.4, 2002, issue 4
Ming-Yu Wang, Qing-Ming Che, Qiang Liu, Zhi-Bin Lin
Mitigating Acetaminophen-Induced Hepatotoxicity by Using a Water-Alcohol Extract of Phellinus caryophylli (Agaricomycetes) in a Murine Model
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 4
Cherupally Krishnan Krishnan Nair, Prasad Y. Lamrood, Yogesh Bharat Dalvi, Ruby Varghese