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Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Biochanin A Enhances the Radiotoxicity in Colon Tumor Cells In Vitro

Volumen 32, Ausgabe 3, 2013, pp. 189-203
DOI: 10.1615/JEnvironPatholToxicolOncol.2013007280
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ABSTRAKT

Herbs and other plant-based compounds have increasingly been recognized as useful for the prevention and treatment of cancer. There exists enormous scope for screening and evaluation of herbal/plant products to develop an effective radiosensitizer and radioprotector that is relevant for cancer therapy. Anticancer agents that can effectively trigger the process of cell death in tumor cells need to be developed. This study describes the effect of the flavonoid biochanin A (BCA), administered alone or in combination with gamma radiation, on the growth of radioresistant human colon cancer HT29 cells in vitro. Proliferation studies were carried out using MTT assay with increasing concentration of BCA (1−100 µM) followed by gamma irradiation at a dose of 2 Gy. Induced reactive oxygen species, mitochondrial membrane potential, lipid peroxidation, and caspase-3 activation were measured by fluorescence assays and the magnitude of induced apoptosis in cells was evaluated by flow cytometry. Cellular DNA damage was determined by comet assay. Combined treatment caused a significant decrease in cell proliferation, a substantial increase in the generation of reactive oxygen species, enhanced lipid peroxidation, and increased mitochondrial membrane potential in treated HT29 cells compared with controls. Significantly enhanced apoptosis and DNA damage were found with a combination of drug and radiation treatments. Furthermore, it was found that combined treatment yielded an additive increase of caspase-3 in these cells. Our findings indicate that BCA acts as a remarkable pro-oxidant, significantly enhancing the radiotoxicity of colon cancer cells in vitro.

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